ReviewMetabolic brain disease2022
Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms.
Review in Metabolic brain disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 2 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Morphological brain changes in high-altitude careers and spaceflights: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- Mechanisms underlying neurocognitive dysfunction following critical illness: a systematic review.Anaesthesia · 2025Pooled it
- Hospital and long-term outcomes for subglottic suction and polyurethane cuff versus standard endotracheal tubes in emergency intubation (PreVent 2): a randomised controlled phase 2 trial.The Lancet. Respiratory medicine · 2026Trial
- Links between nocturnal hypoxia and cognitive function in breast cancer.Scientific reports · 2025Trial
- Examining the impact of obstructive sleep apnea on cognitive function in severe COPD.Sleep & breathing = Schlaf & Atmung · 2024Trial
- Trial
- Review
- Cognitive impairment in chronic respiratory disease patients using long-term oxygen therapy: a narrative review.Medical gas research · 2026Review
- Normoxic brain endurance training is associated with cognitive and oculomotor performance during acute hypoxia.European journal of applied physiology · 2026Article
- The Association Between Hemoglobin Level and Cognitive Function in Older Adults During Hospitalization: A Prospective Observational Study.Health science reports · 2026Article
- Effects of acute severe hypobaric hypoxia on gut-muscle axis in rats.Journal of physiology and biochemistry · 2026Article
- Article
- Progress of Research on Cognitive Impairment in Patients With Chronic Obstructive Pulmonary Disease.Actas espanolas de psiquiatria · 2026Review
- A Modeling Approach to Inform In Vitro Hypoxia Platforms for Patient-Specific Analyses.Annals of biomedical engineering · 2026Article
- Cognition in Chronic Heart Failure: Advancing Knowledge for Better Prevention Through Remote Assessment.CJC open · 2026Article
- Identification of prognostic genes and development of a risk model for pancreatic cancer based on hypoxia- and lipid metabolism-related genes.Discover oncology · 2026Article
- Cognitive Impairment as a Putative Mechanism of Self-Management Failure in Chronic Obstructive Pulmonary Disease: A Conceptual Narrative Review.Journal of clinical medicine · 2026Review
- The systemic impact of acute exacerbations of COPD requiring hospitalisation: a narrative review.ERJ open research · 2026Review
- Effect of Overdose-Induced Hypoxia on Neurocognitive Performance in Individuals With Opioid Dependence: A Prospective Multicenter Study.Alpha psychiatry · 2026Article
- Mechanisms underlying end-organ injury in sleep apnoea.The European respiratory journal · 2026Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both acute and chronic hypoxia could induce abundant neurological deficits. Although there have been significant advances in the pathophysiological injuries, few studies have focused on the cognitive dysfunction. In this review, we focused on the clinical evidences and molecular mechanisms of cognitive impairment under acute and chronic hypoxia. Hypoxia can impair several cognitive domains such as attention, learning and memory, procession speed and executive function, which are similar in acute and chronic hypoxia. The severity of cognitive deficit correlates with the duration and degree of hypoxia. Recovery can be achieved after acute hypoxia, while sequelae or even dementia can be observed after chronic hypoxia, perhaps due to the different molecular mechanisms. Cardiopulmonary compensatory response, glycolysis, oxidative stress, calcium overload, adenosine, mitochondrial disruption, inflammation and excitotoxicity contribute to the molecular mechanisms of cognitive deficit after acute hypoxia. During the chronic stage of hypoxia, different adaptive responses, impaired neurovascular coupling, apoptosis, transcription factors-mediated inflammation, as well as Aβ accumulation and tau phosphorylation account for the neurocognitive deficit. Moreover, brain structural changes with hippocampus and cortex atrophy, ventricle enlargement, senile plaque and neurofibrillary tangle deposition can be observed under chronic hypoxia rather than acute hypoxia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.