Evidence map›Paper›PMID 34619113›Full record

ArticleThe Journal of pediatrics2022

Prevalence Implications of the 2017 American Academy of Pediatrics Hypertension Guideline and Associations with Adult Hypertension.

Michael Khoury, Philip Khoury, Lydia Bazzano, Trudy L Burns, Stephen Daniels, Terence Dwyer, Johanna Ikonen, David R Jacobs, Markus Juonala, Mika Kähönen and 8 more

Open access · greenAbstract readComment
In one paragraph

Article in The Journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 5 countries.

Michael KhouryDepartment of Pediatrics, University of Alberta, Edmonton, Canada. Electronic address: Khoury1@ualberta.ca.
Philip KhouryCincinnati Children's Hospital Medical Center, Cincinnati, OH.
Lydia BazzanoTulane University School of Public Health and Tropical Medicine, New Orleans, LA.
Trudy L BurnsDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA.
Stephen DanielsUniversity of Colorado School of Medicine, Aurora, CO.
Terence DwyerOxford Martin School, Oxford University, Oxford, United Kingdom.
Johanna IkonenCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
David R JacobsUniversity of Minnesota, Minneapolis, MN.
Markus JuonalaDepartment of Medicine, Turku University Hospital, University of Turku, Turku, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Ronald PrineasWake Forest University School of Medicine, Winston-Salem, NC.
Olli T RaitakariCentre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Julia SteinbergerUniversity of Minnesota, Minneapolis, MN.
Alison VennMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
Jorma ViikariDepartment of Medicine, Turku University Hospital, University of Turku, Turku, Finland.
Jessica G WooCincinnati Children's Hospital Medical Center, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH.
Alan SinaikoUniversity of Minnesota, Minneapolis, MN.
Elaine M UrbinaCincinnati Children's Hospital Medical Center, Cincinnati, OH; University of Cincinnati College of Medicine, Cincinnati, OH.
University of Turku · FICincinnati Children's Hospital Medical Center · USUniversity of Minnesota · USTampere University Hospital · FITulane University · USUniversity of Alberta · CAUniversity of Colorado Denver · USUniversity of Iowa · USUniversity of Oxford · GBUniversity of Tasmania · AUWake Forest University · US

Funding

Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
NHLBI NIH HHS R01 HL121230
6 · The paper itself

Abstract

objectiveTo evaluate the impact of the 2017 American Academy of Pediatrics hypertension Clinical Practice Guideline (CPG), compared with the previous guideline ("Fourth Report"), on the frequency of hypertensive blood pressure (BP) measurements in childhood and associations with hypertension in adulthood using data from the International Childhood Cardiovascular Cohort Consortium. STUDY

designChildhood BPs were categorized in normal, prehypertensive/elevated, and hypertensive (stage 1 and 2) ranges using the Fourth Report and the CPG. Participants were contacted in adulthood to assess self-reported hypertension. The associations between childhood hypertensive range BPs and self-reported adult hypertension were evaluated.

resultsData were available for 34 014 youth (10.4 ± 3.1 years, 50.6% female) with 92 751 BP assessments. Compared with the Fourth Report, the CPG increased hypertensive readings from 7.6% to 13.5% and from 1.3% to 2.5% for stage 1 and 2 hypertensive range, respectively (P < .0001). Of 12 761 adults (48.8 ± 7.9 years, 43% male), 3839 (30.1%) had self-reported hypertension. The sensitivity for predicting adult hypertension among those with hypertensive range BPs at any point in childhood, as defined by the Fourth Report and the CPG, respectively, was 13.4% and 22.4% (specificity 92.3% and 85.9%, P < .001), with no significant impact on positive and negative predictive values. Associations with self-reported adult hypertension were similar and weak (c-statistic range 0.61-0.68) for hypertensive range BPs as defined by the Fourth Report and CPG.

conclusionsThe CPG significantly increased the prevalence of childhood BPs in hypertensive ranges and improved the sensitivity, without an overall strengthened association, of predicting self-reported adult hypertension.

Indexed as

HypertensionPediatricsAcademies and InstitutesAdolescentAdultBlood PressureChildFemaleHumansMalePrevalenceUnited Statesguidelinehypertensionpediatricsensitivityspecificity

Identifiers

PMID34619113
PMCPMC8924915
OpenAlexW3202292724

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.