Evidence map›Paper›PMID 34620552›Full record

Observational studyPancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]2022

Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.

Jaimie D Nathan, Yi Yang, Anne Eaton, Piotr Witkowski, Martin Wijkstrom, Matthew Walsh, Guru Trikudanathan, Vikesh K Singh, Sarah J Schwarzenberg, Timothy L Pruett and 17 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Observational
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023
    Observational
  12. Review
  13. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 1 country.

Jaimie D NathanDivision of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address: jaimie.nathan@nationwidechildrens.org.
Yi YangDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Anne EatonDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Piotr WitkowskiDepartment of Surgery, University of Chicago, Chicago, IL, USA.
Martin WijkstromDepartment of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Matthew WalshDepartment of Surgery, Cleveland Clinic, OH, USA.
Guru TrikudanathanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Vikesh K SinghDepartment of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Sarah J SchwarzenbergDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA.
Timothy L PruettDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Andrew PosseltDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Bashoo NaziruddinIslet Cell Processing Laboratory, Baylor Health, Dallas, TX, USA.
Sri Prakash MokshagundamDepartment of Medicine, University of Louisville, Louisville, KY, USA.
Katherine MorganDepartment of Surgery, The Medical University of South Carolina, Charleston, SC, USA.
Luis F LaraDepartment of Medicine, The Ohio State Wexner University Medical Center, Columbus, OH, USA.
Varvara KirchnerDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Jin HeDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Timothy B GardnerDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Martin L FreemanDepartment of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA.
Kate ElleryDepartment of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Darwin L ConwellDepartment of Medicine, The Ohio State Wexner University Medical Center, Columbus, OH, USA.
Srinath ChinnakotlaDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Gregory J BeilmanDepartment of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
Syed AhmadDepartment of Surgery, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
Maisam Abu-El-HaijaDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
James S HodgesDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Melena D BellinDepartment of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA; Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, USA.
University of Minnesota Medical Center · USUniversity of Minnesota · USCincinnati Children's Hospital Medical Center · USJohns Hopkins University · USThe Ohio State University Wexner Medical Center · USUniversity of Pittsburgh Medical Center · USBaylor Scott & White Health · USCleveland Clinic · USDartmouth–Hitchcock Medical Center · USMedical University of South Carolina · USUniversity of California, San Francisco · USUniversity of Chicago · USUniversity of Cincinnati Medical Center · USUniversity of Louisville · US

Funding

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIATR01DK109124 · NIDDK · UNIVERSITY OF MINNESOTA · PI BELLIN, MELENA D. · 2016 to 2021
$4.0M
NIDDK NIH HHS R01 DK109124
6 · The paper itself

Abstract

backgroundTotal pancreatectomy with islet autotransplantation (TPIAT) is a viable option for treating debilitating recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) in adults and children. No data is currently available regarding variation in approach to operation.

methodsWe evaluated surgical techniques, islet isolation and infusion approaches, and outcomes and complications, comparing children (n = 84) with adults (n = 195) enrolled between January 2017 and April 2020 by 11 centers in the United States in the Prospective Observational Study of TPIAT (POST), which was launched in 2017 to collect standard history and outcomes data from patients undergoing TPIAT for RAP or CP.

resultsChildren more commonly underwent splenectomy (100% versus 91%, p = 0.002), pylorus preservation (93% versus 67%; p < 0.0001), Roux-en-Y duodenojejunostomy reconstruction (92% versus 35%; p < 0.0001), and enteral feeding tube placement (93% versus 63%; p < 0.0001). Median islet equivalents/kg transplanted was higher in children (4577; IQR 2816-6517) than adults (2909; IQR 1555-4479; p < 0.0001), with COBE purification less common in children (4% versus 15%; p = 0.0068). Median length of hospital stay was higher in children (15 days; IQR 14-22 versus 11 days; IQR 8-14; p < 0.0001), but 30-day readmissions were lower in children (13% versus 26%, p = 0.018). Rate of portal vein thrombosis was significantly lower in children than in adults (2% versus 10%, p = 0.028). There were no mortalities in the first 90 days post-TPIAT.

conclusionsPancreatectomy techniques differ between children and adults, with islet yields higher in children. The rates of portal vein thrombosis and early readmission are lower in children.

Indexed as

Islets of Langerhans TransplantationLaparoscopyPancreatectomyAcute DiseaseAdultChildFemaleHumansMaleMiddle AgedPancreatitis, ChronicPostoperative ComplicationsProspective StudiesTransplantation, AutologousTreatment OutcomeChronic pancreatitisIslet isolationRecurrent acute pancreatitisSurgical techniquesTotal pancreatectomy with islet autotransplantation

Identifiers

PMID34620552
PMCPMC8748311
OpenAlexW3204809458

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.