Evidence map›Paper›PMID 34622154›Full record

ArticleiScience2021

Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet.

Belinda Yau, Sheyda Naghiloo, Alexis Diaz-Vegas, Austin V Carr, Julian Van Gerwen, Elise J Needham, Dillon Jevon, Sing-Young Chen, Kyle L Hoehn, Amanda E Brandon and 10 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Genetics and diet shape the relationship between islet function and whole body metabolism.American journal of physiology. Endocrinology and metabolism · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Belinda YauDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Sheyda NaghilooDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Alexis Diaz-VegasSchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Austin V CarrDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Julian Van GerwenSchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Elise J NeedhamSchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Dillon JevonDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Sing-Young ChenDepartment of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia.
Kyle L HoehnDepartment of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW 2052, Australia.
Amanda E BrandonDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Laurance MaciaDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Gregory J CooneyDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Michael R ShortreedDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Lloyd M SmithDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
Peter ThornDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Mark LaranceSchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
David E JamesDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
Sean J HumphreySchool of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney, NSW, Australia.
Melkam A KebedeDiscipline of Physiology, School of Medical Sciences, Charles Perkins Centre, University of Sydney, Camperdown 2006, Australia.
The University of Sydney · AUUniversity of Wisconsin–Madison · USUNSW Sydney · AU

Funding

Sequence-specific Hybridization Capture to Reveal the lncRNA Interactome in Prostate CancerR01CA193481 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI DAVID F. JARRARD, Lloyd M Smith · 2015 to 2026
$3.4M
NCI NIH HHS R01 CA193481
6 · The paper itself

Abstract

Pancreatic islets are essential for maintaining physiological blood glucose levels, and declining islet function is a hallmark of type 2 diabetes. We employ mass spectrometry-based proteomics to systematically analyze islets from 9 genetic or diet-induced mouse models representing a broad cross-section of metabolic health. Quantifying the islet proteome to a depth of >11,500 proteins, this study represents the most detailed analysis of mouse islet proteins to date. Our data highlight that the majority of islet proteins are expressed in all strains and diets, but more than half of the proteins vary in expression levels, principally due to genetics. Associating these varied protein expression levels on an individual animal basis with individual phenotypic measures reveals islet mitochondrial function as a major positive indicator of metabolic health regardless of strain. This compendium of strain-specific and dietary changes to mouse islet proteomes represents a comprehensive resource for basic and translational islet cell biology.

Indexed as

animal physiologydiabetologyproteomics

Identifiers

PMID34622154
PMCPMC8479695
OpenAlexW3198565958

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.