Evidence map›Paper›PMID 34622673›Full record

ArticleJournal of the American Heart Association2021

Induction of Heme Oxygenase-1 Is Linked to the Severity of Disease in Human Abdominal Aortic Aneurysm.

Anja Hofmann, Margarete Müglich, Steffen Wolk, Yazan Khorzom, Pamela Sabarstinski, Irakli Kopaliani, Dmitry Egorov, Franziska Horn, Coy Brunssen, Sindy Giebe and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Dihydromyricetin mitigates abdominal aortic aneurysmActa pharmaceutica Sinica. B · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Anja HofmannDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID 0000-0002-1490-6474
Margarete MüglichDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID 0000-0002-5750-5195
Steffen WolkDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Yazan KhorzomDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Pamela SabarstinskiDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID 0000-0001-5732-8312
Irakli KopalianiDepartment of Physiology Medical Faculty Carl Gustav Carus Dresden Technische Universität Dresden Dresden Germany.
Dmitry EgorovDepartment of Physiology Medical Faculty Carl Gustav Carus Dresden Technische Universität Dresden Dresden Germany.
Franziska HornDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID 0000-0002-2727-9457
Coy BrunssenDivision of Vascular Endothelium and Microcirculation Department of Medicine III University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Sindy GiebeDivision of Vascular Endothelium and Microcirculation Department of Medicine III University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Bianca HamannDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Andreas DeussenDepartment of Physiology Medical Faculty Carl Gustav Carus Dresden Technische Universität Dresden Dresden Germany.
Henning MorawietzDivision of Vascular Endothelium and Microcirculation Department of Medicine III University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID 0000-0001-9360-9736
David M PoitzInstitute for Clinical Chemistry and Laboratory Medicine University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
Christian ReepsDivision of Vascular and Endovascular Surgery Department of Visceral, Thoracic and Vascular Surgery University Hospital and Medical Faculty Carl Gustav Carus Technische Universität Dresden Dresden Germany.
University Hospital Carl Gustav Carus · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Rupture of abdominal aortic aneurysm (rAAA) is associated with high case fatality rates, and risk of rupture increases with the AAA diameter. Heme oxygenase-1 (gene

Indexed as

Aortic Aneurysm, AbdominalHeme Oxygenase-1AnimalsHumansMiceSeverity of Illness IndexHeme Oxygenase-1abdominal aortic aneurysmheme oxygenaserupture

Identifiers

PMID34622673
PMCPMC8751892
OpenAlexW3202771184

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.