ArticleeLife2021
Evolutionary transcriptomics implicates new genes and pathways in human pregnancy and adverse pregnancy outcomes.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- Calm in the midst of the storm: inferring gene expression stability in flowering plants.Frontiers in plant science · 2026Article
- An evolutionary genomic perspective on preterm birth, genome editing, and pregnancy in the human species.Frontiers in genome editing · 2026Review
- Reframing the significance of menstruation: evolutionary insights from an organismal-relational perspective.History and philosophy of the life sciences · 2025Article
- Cell type and cell signalling innovations underlying mammalian pregnancy.Nature ecology & evolution · 2025Article
- Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait.Molecular biology and evolution · 2025Article
- The BulkECexplorer compiles endothelial bulk transcriptomes to predict functional versus leaky transcription.Nature cardiovascular research · 2024Article
- Changes in Immune Response during Pig Gestation with a Focus on Cytokines.Veterinary sciences · 2024Review
- Progressive Exaptation of Endogenous Retroviruses in Placental Evolution in Cattle.Biomolecules · 2023Review
- Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia.International journal of molecular sciences · 2023Review
- Article
- Gene expression dynamics of natural assemblages of heterotrophic flagellates during bacterivory.Microbiome · 2023Article
- Human embryo implantation.Development (Cambridge, England) · 2023Review
- Transposable Elements Continuously Remodel the Regulatory Landscape, Transcriptome, and Function of Decidual Stromal Cells.Genome biology and evolution · 2022Article
- Maternal selection of human embryos in early gestation: Insights from recurrent miscarriage.Seminars in cell & developmental biology · 2022Review
- Young transposable elements rewired gene regulatory networks in human and chimpanzee hippocampal intermediate progenitors.Development (Cambridge, England) · 2022Article
- Article
- Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells.PLoS genetics · 2022Article
- Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells.Scientific reports · 2022Article
- Review
- The Role of Decidual Subpopulations in Implantation, Menstruation and Miscarriage.Frontiers in reproductive health · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Evolutionary changes in the anatomy and physiology of the female reproductive system underlie the origins and diversification of pregnancy in Eutherian ('placental') mammals. This developmental and evolutionary history constrains normal physiological functions and biases the ways in which dysfunction contributes to reproductive trait diseases and adverse pregnancy outcomes. Here, we show that gene expression changes in the human endometrium during pregnancy are associated with the evolution of human-specific traits and pathologies of pregnancy. We found that hundreds of genes gained or lost endometrial expression in the human lineage. Among these are genes that may contribute to human-specific maternal-fetal communication (
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.