Evidence map›Paper›PMID 34624617›Full record

ArticleStem cell research2021

Increasing cytosolic Ca

Naseem Ahamad, Yuyang Sun, Brij B Singh

Open access · goldAbstract read
In one paragraph

Article in Stem cell research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Store-Operated CaJournal of clinical medicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Naseem AhamadDepartment of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, United States.
Yuyang SunDepartment of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, United States.
Brij B SinghDepartment of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, United States.
The University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUM1TR004538 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ROBERT A CLARK, Kenneth M Hargreaves · 2023 to 2026
$22.3M
Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5M
TRPC1, Calcium, and Saliva SecretionR01DE017102 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Brij B Singh · 2006 to 2026
$7.5M
Calcium entry modulates stem cell proliferationR21DE028265 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SINGH, BRIJ B · 2019 to 2020
$423k
NCATS NIH HHS UL1 TR001120NCATS NIH HHS UM1 TR004538NCI NIH HHS P30 CA054174NIDCR NIH HHS R01 DE017102NIDCR NIH HHS R21 DE028265
6 · The paper itself

Abstract

Aging is an inescapable complex physiological but extendable process, and all cells, including stem cells, are altered over time. Diverse mechanism(s) could modulate stem cell number, their proliferation rate, and promote tissue repair during aging that leads to longevity. However, the factors that could restore aging stem cell potency and would lead to healthy aging are not fully identified. Here we show that maintaining cytosolic Ca

Indexed as

Calcium ChannelsMesenchymal Stem CellsAnimalsCalciumCell ProliferationCells, CulturedMiceORAI1 ProteinStem CellsStromal Interaction Molecule 1TRPC Cation ChannelsCalciumCalcium ChannelsORAI1 ProteinStromal Interaction Molecule 1TRPC Cation ChannelsAged stem cells and potencyCalcium channelsCell proliferation/cell cycleCell viabilityStem cell function

Identifiers

PMID34624617
PMCPMC8596392
OpenAlexW3203687203

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.