ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2022
Energetic Cost of Walking and Brain Atrophy in Mid-to-Late Life.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed.
- Heterogeneity Within Frailty: Physiological Reserve Phenotypes and Postoperative Recovery After Abdominal Surgery.Journal of clinical medicine · 2026Article
- Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association of mitochondrial oxidative capacity with physical fitness in ageing: the Baltimore longitudinal study of ageing.Age and ageing · 2026Article
- Physical Activity Patterns and Variability, Cognitive Performance, and Dementia in the National Health and Aging Trends Study.Medicine and science in sports and exercise · 2025Article
- Transfemoral limb loss modestly increases the metabolic cost of optimal control simulations of walking.PeerJ · 2024Article
- Association between walking energy utilisation and longitudinal cognitive performance in older adults.Age and ageing · 2022Article
- Walking energetics and white matter hyperintensities in mid-to-late adulthood.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Lower CD8+ T-cell senescence partially mediates the neuroprotection of higher aerobic fitness.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundHigher energetic costs for mobility are associated with declining gait speed, and slow gait is linked to cognitive decline and Alzheimer's disease. However, the physiological underpinnings of gait and brain health have not been well explored. We examined the associations of the energetic cost of walking with brain volume in cognitively unimpaired adults from the Baltimore Longitudinal Study of Aging.
methodsWe used brain magnetic resonance imaging (MRI) data from 850 participants (mean baseline age 66.3 ± 14.5 years), of whom 451 had longitudinal MRI data (2.8 ± 1.0 MRI scans over 4.0 ± 2.0 years). The energetic cost of walking was assessed as the average energy expended (V̇O2) during 2.5 minutes of customary-paced overground walking. Multivariable linear mixed-effects models examined the associations between baseline energetic cost of walking and regional brain volumes adjusting for covariates.
resultsAt baseline, higher energetic cost of walking was cross-sectionally associated with lower gray and white matter volumes within the frontal, parietal, and temporal lobes, as well as hippocampal, total brain, and larger ventricular volumes (all false-discovery rate [FDR] p < .05). A baseline energetic cost of walking × time interaction demonstrated that participants with higher energetic cost of walking had faster annual decline in hippocampal volume (FDR p = .02) and accelerated annual increase in ventricular volumes (FDR p = .02).
conclusionsThe energetic cost of walking is associated with gray and white matter volumes and subsequent hippocampal atrophy and ventricular enlargement. Collectively, these data suggest the energetic cost of walking may be an early marker of neurodegeneration that contributes to the gait brain connection.
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Registered trials
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