Evidence map›Paper›PMID 34630739›Full record

ArticleDisease markers2021

Pericytes of Indirect Contact Coculture Decrease Integrity of Inner Blood-Retina Barrier Model

Tianye Yang, Liang Guo, Yuan Fang, Mingli Liang, Yongzheng Zheng, Mingdong Pan, Chun Meng, Guanghui Liu

Open access · hybridAbstract read
In one paragraph

Article in Disease markers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tianye YangDepartment of Bioengineering, College of Biological Science and Biotechnology, Fuzhou University, Fuzhou, Fujian, China.
Liang GuoDepartment of Bioengineering, College of Biological Science and Biotechnology, Fuzhou University, Fuzhou, Fujian, China.
Yuan FangDepartment of Ophthalmology, Affiliated People's Hospital (Fujian Provincial People's Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Mingli LiangDepartment of Bioengineering, College of Biological Science and Biotechnology, Fuzhou University, Fuzhou, Fujian, China.
Yongzheng ZhengDepartment of Ophthalmology, Affiliated People's Hospital (Fujian Provincial People's Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Mingdong PanDepartment of Ophthalmology, Affiliated People's Hospital (Fujian Provincial People's Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.
Chun MengDepartment of Bioengineering, College of Biological Science and Biotechnology, Fuzhou University, Fuzhou, Fujian, China.ORCID https://orcid.org/0000-0002-9085-168X
Guanghui LiuDepartment of Ophthalmology, Affiliated People's Hospital (Fujian Provincial People's Hospital), Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, China.ORCID https://orcid.org/0000-0003-2064-4156
Fujian University of Traditional Chinese Medicine · CNFuzhou University · CNLuye Pharma (China) · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inner blood-retina barrier (iBRB) is primarily formed of retinal microvascular endothelial cells (ECs) with tight junctions, which are surrounded and supported by retinal microvascular pericytes (RMPs) and basement membrane. Pericytes are believed to be critically involved in the physiology and pathology of iBRB. However, the underlying mechanism remains to be fully elucidated. We developed a novel

Indexed as

AnimalsBlood-Retinal BarrierCell MovementCells, CulturedCoculture TechniquesEndothelial CellsMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Models, BiologicalPericytesPrimary Cell CultureRatsRetinaTight JunctionsMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, ratMmp9 protein, rat

Identifiers

PMID34630739
PMCPMC8494570
OpenAlexW3202781577

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.