Evidence map›Paper›PMID 34630872›Full record

ReviewWorld journal of hepatology2021

Herbal and dietary supplement induced liver injury: Highlights from the recent literature.

Stephanie M Woo, William D Davis, Soorya Aggarwal, Joseph W Clinton, Sara Kiparizoska, James H Lewis

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Observational
  3. Efficacy and Safety ofFoods (Basel, Switzerland) · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. A Review of the Mechanisms and Risks ofDiseases (Basel, Switzerland) · 2025
    Review
  10. Oral Supplementation ofAnimals : an open access journal from MDPI · 2025
    Article
  11. Challenges in herbal-induced liver injury identification and prevention.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Hepatotoxicity due to herbal dietary supplements: Past, present and the future.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2022
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Stephanie M WooDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States. stephanie.m.woo@medstar.net.
William D DavisDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States.
Soorya AggarwalDepartment of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC 20007, United States.
Joseph W ClintonDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States.
Sara KiparizoskaDepartment of Internal Medicine, MedStar Georgetown University Hospital, Washington, DC 20007, United States.
James H LewisDepartment of Gastroenterology, MedStar Georgetown University Hospital, Washington, DC 20007, United States.
Georgetown University · USMedStar Georgetown University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herbal-induced liver injury (HILI) is an important and increasingly concerning cause of liver toxicity, and this study presents recent updates to the literature. An extensive literature review was conducted encompassing September 2019 through March 2021. Studies with clinically significant findings were analyzed and included in this review. We emphasized those studies that provided a causality assessment methodology, such as Roussel Uclaf Causality Assessment Method scores. Our review includes reports of individual herbals, including

Indexed as

Dietary supplement-induced liver injuryDrug-induced liver injuryHepatotoxicityHerbal-induced liver injuryLiver toxicityRoussel Uclaf Causality Assessment Method

Identifiers

PMID34630872
PMCPMC8473494
OpenAlexW3201536421

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.