ArticleEuropean journal of nutrition2022
Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.
Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Whole Dietary Patterns, Cognitive Decline and Cognitive Disorders: A Systematic Review of Prospective and Intervention Studies.Nutrients · 2023Pooled it
- Consumption of ultra-processed foods and risk for Alzheimer's disease: a systematic review.Frontiers in nutrition · 2023Pooled it
- Early-life nutritional environment is associated with late-life cognition in the Health and Retirement Study, a pellagra epidemic natural experiment.medRxiv : the preprint server for health sciences · 2026Article
- High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence From a 25-Year Prospective Cohort Study.Neurology · 2026Article
- From plate to brain: role of mediators and moderators on the impact of diet on Alzheimer's disease.Frontiers in nutrition · 2026Review
- APOE-ε4 moderates the association between diet quality and executive function in middle-aged women at increased risk for Alzheimer's disease.Journal of nutritional science · 2026Article
- Association between high carbohydrate to dietary fiber ratio and risk of dementia in older adults: analysis from the UK biobank.BMC neurology · 2025Article
- Article
- Impact of Diverse Dietary Patterns on Cognitive Health: Cumulative Evidence from Prospective Cohort Studies.Nutrients · 2025Review
- Taurine Intake, Plasma Taurine Concentration, and Dementia Risk: Findings From the Malmö Diet and Cancer Study.Journal of neurochemistry · 2025Article
- Translating Alzheimer's Disease Mechanisms into Therapeutic Opportunities.Biomolecules · 2025Review
- Associations between the EAT-Lancet planetary health diet and incident dementia.The journal of prevention of Alzheimer's disease · 2025Article
- The associations between fresh vegetable and fruit consumption and plasma and PET biomarkers in preclinical Alzheimer's disease: A cross-sectional and longitudinal study of Chinese population.The journal of prevention of Alzheimer's disease · 2025Article
- Association of dietary diversity, genetic susceptibility, and the risk of incident dementia: A prospective cohort study.The journal of prevention of Alzheimer's disease · 2025Article
- Neuroimaging Correlates of 3 Distinct Physical-Cognitive Phenotypes in Cognitively Normal Older Adults: The Gothenburg H70 Cohort Study.Neurology · 2025Article
- Empirically derived dietary patterns in relation to periodontitis and number of teeth among Norwegian adults.Public health nutrition · 2024Article
- Ideal vitamin D and handgrip strength counteracts the risk effect of APOE genotype on dementia: a population-based longitudinal study.Journal of translational medicine · 2023Article
- Reader Response: Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period.Neurology · 2023Article
- Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: findings from the UK Biobank prospective cohort study.BMC medicine · 2023Article
- Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching.BMC geriatrics · 2023Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
purposeTo investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer's disease (AD) in relation to incident dementia.
methodsData were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992-93, or 2000-02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene-diet interactions in relation to incident dementia were analysed with Cox regression models. The interaction p value threshold was < 0.1.
resultsThere were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21).
conclusionsThe results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia.
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