Evidence map›Paper›PMID 34634300›Full record

ArticlePharmacology, biochemistry, and behavior2021

Ethanol pre-exposure differentially impacts the rewarding and aversive effects of α-pyrrolidinopentiophenone (α-PVP): Implications for drug use and abuse.

Katharine H Nelson, Hayley N Manke, Jacob M Bailey, Anna Vlachos, Karina J Maradiaga, Shihui Huang, Tania D Weiss, Kenner C Rice, Anthony L Riley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Katharine H NelsonPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA. Electronic address: kn9165a@american.edu.
Hayley N MankePsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Jacob M BaileyPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Anna VlachosPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Karina J MaradiagaPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Shihui HuangPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Tania D WeissPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA.
Kenner C RiceDrug Design and Synthesis Section, National Institute on Drug Abuse (NIDA), National Institute on Alcohol Abuse and Alcoholism (NIAAA), Bethesda, MD 20892, USA.
Anthony L RileyPsychopharmacology Laboratory, Department of Neuroscience, Center for Neuroscience and Behavior, American University, 4400 Massachusetts Ave, NW, Washington, D. C. 20016, USA. Electronic address: nelsokat@musc.edu.
American University · USNational Institute on Alcohol Abuse and Alcoholism · US

Funding

Medicinal Chemistry of Drugs Acting on Biogenic Amine ReceptorsZ01DA000532 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI RICE, KENNER · 2008 to 2008
$117k
Intramural NIH HHS Z01 DA000532
6 · The paper itself

Abstract

rationaleExposure to a drug can subsequently impact its own reactivity as well as that of other drugs. Given that users of synthetic cathinones, i.e., "bath salts", typically have extensive and varied drug histories, an understanding of the effects of drug history on the behavioral and physiological consequences of synthetic cathiones may be important to their abuse liability.

objectivesThe goal of the current work was to assess the effects of an ethanol pre-exposure on the rewarding and aversive effects of α-PVP.

methodsAdult male Sprague Dawley rats were exposed to ethanol prior to combined conditioned taste avoidance/conditioned place preference training in which rats were injected with 1.5, 3 or 5 mg/kg of racemic α-PVP or vehicle. Following a 7-day washout period, rats were then tested for thermoregulatory effects of α-PVP using subcutaneous probes to measure body temperature changes over the course of 8 h. This was followed 10 days later by assessments for α-PVP-induced locomotor activity and stereotypies over a 1-h session.

resultsα-PVP induced significant dose- and trial-dependent taste avoidance that was significantly attenuated by ethanol history and dose- and time-dependent increases in locomotor activity that were significantly increased by ethanol. α-PVP also induced place preferences and dose- and time-dependent increases in body temperature, but these measures were unaffected by ethanol history.

conclusionsα-PVP's aversive effects (as measured by taste avoidance) were attenuated, while its rewarding effects (as indexed by place preference conditioning) were unaffected, by ethanol pre-exposure. Such a pattern may indicate increased α-PVP abuse liability, as changes in the balance of aversion and reward may impact overall drug effects and likelihood of drug intake. Future self-administration studies will be necessary to explore this possibility.

Indexed as

RewardAlkaloidsAnimalsAvoidance LearningBody TemperatureCentral Nervous System StimulantsConditioning, ClassicalEthanolLocomotionMalePentanonesPyrrolidinesRatsRats, Sprague-DawleySelf AdministrationSubstance-Related Disorders1-phenyl-2-(1-pyrrolidinyl)-1-pentanoneAlkaloidscathinoneCentral Nervous System StimulantsEthanolPentanonesPyrrolidinesConditioned place preferenceConditioned taste avoidanceDrug historyEthanolPre-exposureα-pyrrolidinopentiophenone

Identifiers

PMID34634300
PMCPMC8643339
OpenAlexW3202238079

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.