Evidence map›Paper›PMID 34636197›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2021

Effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma.

Kai Zhao, Wen-Hong Yuan, Wen-Jian Li, Zeng-Peng Chi, Shao-Ru Wang, Zheng-Gang Chen

Open access · greenAbstract read
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kai ZhaoSchool of Stomatology, Qingdao University, Qingdao 266003, China.
Wen-Hong YuanDept. of Stomatology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.
Wen-Jian LiSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Zeng-Peng ChiCollege of Stomatology, Weifang Medical University, Weifang 261021, China.
Shao-Ru WangSchool of Stomatology, Dalian Medical University, Dalian 116044, China.
Zheng-Gang ChenDept. of Stomatology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China.
Dalian Medical University · CNQingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aims to investigate the effect of RhoE expression on the migration and invasion of tongue squamous cell carcinoma (TSCC).

methodsForty-eight TSCC cases were selected from the Maxillofacial Surgery Center of Qingdao Municipal Hospital from 2017 to 2019. The expression of RhoE in the specimens (TSCC and adjacent tissues) was detected by immunohistochemistry, and RhoE mRNA and protein were extracted to further detect the expression of RhoE. SCC-4 and CAL-27 cells were selected for

resultsThe expression level of RhoE in TSCC was significantly lower than that in adjacent tissues (

conclusionsRhoE expression is low in TSCC. Over expression RhoE in TSCC can significantly decrease its migration and invasion abilities. Hence, RhoE may play an important role in regulating the metastasis and invasion of TSCC and provide a new target for gene therapy.

Indexed as

Carcinoma, Squamous CellTongue NeoplasmsCell Line, TumorHumansMatrix Metalloproteinase 2Neoplasm Invasivenessrho-Associated Kinasesrho GTP-Binding ProteinsTongueMatrix Metalloproteinase 2rho-Associated Kinasesrho GTP-Binding ProteinsRND3 protein, humanROCK1 protein, humaninvasionmigrationRhoEtongue squamous cell carcinoma

Identifiers

PMID34636197
PMCPMC8548219
OpenAlexW3207404782

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.