Evidence map›Paper›PMID 34637682›Full record

ArticleBioengineered2021

A novel circular RNA circ_HN1/miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network regulates gastric cancer development.

Jianmin Zhang, Fang Wang, Haihui Zhang, Mingbo Cao

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jianmin ZhangDepartment of Digestive Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Fang WangDepartment of Pharmaceutical Laboratory, Henan Vocational College of Nursing, Anyang, China.
Haihui ZhangDepartment of Digestive Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Mingbo CaoDepartment of Digestive Medicine, Henan Provincial People's Hospital, Zhengzhou, China.ORCID 0000-0002-6445-2685
Henan Provincial People's Hospital · CNHenan Forestry Vocational College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The competing endogenous RNA (ceRNA) activity of circular RNAs (circRNAs) has been implicated in the development of gastric cancer. Here, we sought to explore the ceRNA function of circRNA Jupiter microtubule associated homolog 1 (circ_HN1) in gastric tumorigenesis. Circ_HN1, microRNA (miR)-628-5p, and NT5E expression levels were quantified by qRT-PCR and western blot. Dual-luciferase reporter assays were used to assess the direct relationship between miR-628-5p and circ_HN1 or NT5E. Our data showed that circ_HN1 expression was enhanced in human gastric cancer. Depletion of circ_HN1 impeded cell proliferation, spheroid formation, invasion, and migration and promoted apoptosis

Indexed as

5'-NucleotidaseAgedCell Line, TumorFemaleGPI-Linked ProteinsHumansMaleMicroRNAsMiddle AgedNeoplasm ProteinsRNA, CircularRNA, NeoplasmStomach Neoplasms5'-NucleotidaseGPI-Linked ProteinsMicroRNAsMIRN628 microRNA, humanNeoplasm ProteinsNT5E protein, humanRNA, CircularRNA, NeoplasmceRNA crosstalkCirc_HN1gastric cancermiR-628-5pNT5E

Identifiers

PMID34637682
PMCPMC8810003
OpenAlexW3205698066

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.