Evidence map›Paper›PMID 34638832›Full record

ArticleInternational journal of molecular sciences2021

P2X4 Receptors Mediate Ca

Sin-Lih Tan, Muruj Barri, Peace Atakpa-Adaji, Colin W Taylor, Ewan St John Smith, Ruth D Murrell-Lagnado

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Medial Olivocochlear Efferent Modulation of Cochlear Micromechanics Requires P2X4 Receptor in Outer Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Review
  4. Review
  5. Article
  6. Purinergic P2 Receptors: Structure and Function 2.0.International journal of molecular sciences · 2023
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Sin-Lih TanDepartment of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Muruj BarriSchool of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.
Peace Atakpa-AdajiDepartment of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Colin W TaylorDepartment of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Ewan St John SmithDepartment of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.
Ruth D Murrell-LagnadoSchool of Life Sciences, University of Sussex, Brighton BN1 9QG, UK.ORCID 0000-0003-2743-7977
University of Cambridge · GBUniversity of Sussex · GBAstraZeneca (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The P2X4 purinergic receptor is targeted to endolysosomes, where it mediates an inward current dependent on luminal ATP and pH. Activation of P2X4 receptors was previously shown to trigger lysosome fusion, but the regulation of P2X4 receptors and their role in lysosomal Ca

Indexed as

Calcium SignalingAnimalsCalciumHeLa CellsHumansIntracellular MembranesLysosomesRatsReceptors, Histamine H1Receptors, Purinergic P2X4Receptors, Purinergic P2X7CalciumP2RX7 protein, humanReceptors, Histamine H1Receptors, Purinergic P2X4Receptors, Purinergic P2X7Ca2+lysosomesP2X4

Identifiers

PMID34638832
PMCPMC8508626
OpenAlexW3203198166

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.