Evidence map›Paper›PMID 34638901›Full record

ArticleInternational journal of molecular sciences2021

Mechanisms Involved in the Promoting Activity of Fibroblasts in HTLV-1-Mediated Lymphomagenesis: Insights into the Plasticity of Lymphomatous Cells.

Giulia Rigotto, Barbara Montini, Adriana Mattiolo, Nayana Lazzari, Maria Assunta Piano, Daniel Remondini, Sandra Marmiroli, Jessika Bertacchini, Luigi Chieco-Bianchi, Maria Luisa Calabrò

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Giulia RigottoImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Barbara MontiniImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Adriana MattioloImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Nayana LazzariImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Maria Assunta PianoImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0002-7701-887X
Daniel RemondiniDepartment of Physics and Astronomy, University of Bologna, and Istituto Nazionale di Fisica Nucleare, INFN, 40127 Bologna, Italy.ORCID 0000-0003-3185-7456
Sandra MarmiroliDepartment of Biomedical, Metabolic and Neuronal Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.ORCID 0000-0001-5545-9319
Jessika BertacchiniDepartment of Biomedical, Metabolic and Neuronal Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Luigi Chieco-BianchiDepartment of Surgery, Oncology and Gastroenterology, University of Padua, 35128 Padua, Italy.
Maria Luisa CalabròImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.ORCID 0000-0001-9401-6182
Istituto Oncologico Veneto · ITUniversity of Modena and Reggio Emilia · ITIstituto Nazionale di Fisica Nucleare · ITUniversity of Padua · IT

Funding

5X1000-IOV2017 J92F17000030001
6 · The paper itself

Abstract

Among the mechanisms leading to progression to Adult T-cell Leukaemia/Lymphoma in Human T-cell Leukaemia Virus type 1 (HTLV-1)-infected subjects, the contribution of stromal components remains poorly understood. To dissect the role of fibroblasts in HTLV-1-mediated lymphomagenesis, transcriptome studies, cytofluorimetric and qRT-PCR analyses of surface and intracellular markers linked to plasticity and stemness in coculture, and in vivo experiments were performed. A transcriptomic comparison between a more lymphomagenic (C91/III) and the parental (C91/PL) cell line evidenced hyperactivation of the PI3K/Akt pathway, confirmed by phospho-ELISA and 2-DE and WB analyses. C91/III cells also showed higher expression of mesenchymal and stemness genes. Short-term coculture with human foreskin fibroblasts (HFF) induced these features in C91/PL cells, and significantly increased not only the cancer stem cells (CSCs)-supporting CD10

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAspirinCell LineCells, CulturedCoculture TechniquesFibroblastsGene Expression ProfilingGene Expression Regulation, NeoplasticHumansHuman T-lymphotropic virus 1Jurkat CellsLymphomaMiceMice, Inbred NODMice, KnockoutAnti-Inflammatory Agents, Non-SteroidalAspirinATLLcancer stem cellsHTLV-1lymphomagenesisplasticitystemness

Identifiers

PMID34638901
PMCPMC8508730
OpenAlexW3204875052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.