Evidence map›Paper›PMID 34639136›Full record

ArticleInternational journal of molecular sciences2021

Lecithin Inclusion by α-Cyclodextrin Activates SREBP2 Signaling in the Gut and Ameliorates Postprandial Hyperglycemia.

Eunyoung Lee, Xilin Zhang, Tomoe Noda, Junki Miyamoto, Ikuo Kimura, Tomoaki Tanaka, Kenichi Sakurai, Ryo Hatano, Takashi Miki

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Eunyoung LeeDepartment of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Xilin ZhangDepartment of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Tomoe NodaDepartment of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Junki MiyamotoDepartment of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu 183-8509, Japan.
Ikuo KimuraLaboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.
Tomoaki TanakaDepartment of Molecular Diagnosis, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0002-9761-1750
Kenichi SakuraiCenter for Preventive Medical Sciences, Chiba University, Chiba 263-8522, Japan.
Ryo HatanoDepartment of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Takashi MikiDepartment of Medical Physiology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.ORCID 0000-0001-5741-1626
Chiba University · JPKyoto University · JPTokyo University of Agriculture and Technology · JP

Funding

Japan Society for the Promotion of Science 19K06757 and 19K07281
6 · The paper itself

Abstract

backgroundα-cyclodextrin (α-CD) is one of the dietary fibers that may have a beneficial effect on cholesterol and/or glucose metabolism, but its efficacy and mode of action remain unclear.

methodsIn the present study, we examined the anti-hyperglycemic effect of α-CD after oral loading of glucose and liquid meal in mice.

resultsAdministration of 2 g/kg α-CD suppressed hyperglycemia after glucose loading, which was associated with increased glucagon-like peptide 1 (GLP-1) secretion and enhanced hepatic glucose sequestration. By contrast, 1 g/kg α-CD similarly suppressed hyperglycemia, but without increasing secretions of GLP-1 and insulin. Furthermore, oral α-CD administration disrupts lipid micelle formation through its inclusion of lecithin in the gut luminal fluid. Importantly, prior inclusion of α-CD with lecithin in vitro nullified the anti-hyperglycemic effect of α-CD in vivo, which was associated with increased intestinal mRNA expressions of SREBP2-target genes

conclusionsα-CD elicits its anti-hyperglycemic effect after glucose loading by inducing lecithin inclusion in the gut lumen and activating SREBP2, which is known to induce cholecystokinin secretion to suppress hepatic glucose production via a gut/brain/liver axis.

Indexed as

Postprandial Periodalpha-CyclodextrinsAnimalsGastrointestinal TractHyperglycemiaKcnj11 ChannelLecithinsMaleMiceMice, Inbred C57BLMice, KnockoutPotassium Channels, Inwardly RectifyingSterol Regulatory Element Binding Protein 2alpha-cyclodextrinalpha-CyclodextrinsKcnj11 ChannelLecithinsPotassium Channels, Inwardly RectifyingSrebf2 protein, mouseSterol Regulatory Element Binding Protein 2GLP-1hyperglycemiainclusionlecithinSREBP2α-cyclodextrin

Identifiers

PMID34639136
PMCPMC8509185
OpenAlexW3201717252

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.