Evidence mapPaperPMID 34641429Full record

SynthesisMolecules (Basel, Switzerland)2021

A Systematic Review of the Biological Effects of Cordycepin.

Masar Radhi, Sadaf Ashraf, Steven Lawrence, Asta Arendt Tranholm, Peter Arthur David Wellham, Abdul Hafeez, Ammar Sabah Khamis, Robert Thomas, Daniel McWilliams, Cornelia Huiberdina de Moor

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 82 citations in OpenAlex.

  1. FungalInternational journal of molecular sciences · 2026
    Article
  2. Cordycepin alleviates nicotine withdrawal-induced anxietyDrug and alcohol dependence reports · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Reconstruction of a Genome-Scale Metabolic Model forInternational journal of molecular sciences · 2025
    Article
  12. Article
  13. Telomere-to-Telomere Assembly of theJournal of fungi (Basel, Switzerland) · 2025
    Article
  14. Article
  15. ThePharmaceuticals (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Masar RadhiPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UK.
Sadaf AshrafAberdeen Centre for Arthritis and Musculoskeletal Health, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK.
Steven LawrenceSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Asta Arendt TranholmPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UK.
Peter Arthur David WellhamSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Abdul HafeezSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Ammar Sabah KhamisSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK.
Robert ThomasThe Primrose Oncology Unit, Bedford Hospital NHS Trust, Bedford MK42 9DJ, UK.
Daniel McWilliamsPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-0581-1895
Cornelia Huiberdina de MoorPain Centre Versus Arthritis, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0001-8776-0085
University of Nottingham · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M008770/1Versus Arthritis 20795Versus Arthritis 21586
6 · The paper itself

Abstract

We conducted a systematic review of the literature on the effects of cordycepin on cell survival and proliferation, inflammation, signal transduction and animal models. A total of 1204 publications on cordycepin were found by the cut-off date of 1 February 2021. After application of the exclusion criteria, 791 papers remained. These were read and data on the chosen subjects were extracted. We found 192 papers on the effects of cordycepin on cell survival and proliferation and calculated a median inhibitory concentration (IC

Indexed as

AnimalsAntineoplastic AgentsBrain DiseasesDeoxyadenosinesHumansInflammationMetabolic DiseasesNeoplasmsSignal TransductionAntineoplastic AgentscordycepinDeoxyadenosinesAKTAMPKcell viabilitycordycepinERKinflammationmTORnatural productreviewsignal transduction

Identifiers

PMID34641429
PMCPMC8510467
OpenAlexW3203429162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.