ArticleCancer research2021
Myeloid-Derived Suppressive Cell Expansion Promotes Melanoma Growth and Autoimmunity by Inhibiting CD40/IL27 Regulation in Macrophages.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 29 citations in OpenAlex.
- Evaluation of Antibodies Induced by Melanoma Helper Peptide Vaccine and Their Modulation by Vaccine Adjuvants.Vaccines · 2026Article
- Deficiency of SMARCB1 drives an immunosuppressive microenvironment in meningioma.Acta neuropathologica communications · 2026Article
- The microbiome-inflammation-immune axis in oral squamous cell carcinoma: from mechanistic insights to therapeutic perspectives.Frontiers in immunology · 2026Review
- IL27 expression and IL27RA-dependent cellular responses are associated with biochemical recurrence and immune-regulatory features in prostate cancer.Frontiers in immunology · 2026Article
- The role of tumor necrosis factor receptor superfamily in cancer: insights into oncogenesis, progression, and therapeutic strategies.NPJ precision oncology · 2025Review
- Targeted Deletion of Cxcl1 in MSCs Regulates Osteogenesis and Suppresses Bone-Metastatic Prostate Cancer.Molecular cancer research : MCR · 2025Article
- Tumor Microenvironmental Dynamics in Shaping Resistance to Therapeutic Interventions in Melanoma: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The microbiome as a therapeutic co-driver in melanoma immuno-oncology.Frontiers in medicine · 2025Review
- Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer.Journal of advanced research · 2025Review
- The impact of the tumor microenvironment on macrophages.Frontiers in immunology · 2025Review
- Modulation of the immune microenvironment using nanomaterials: a new strategy for tumor immunotherapy.Frontiers in immunology · 2025Review
- Focusing on the interplay between tumor-associated macrophages and tumor microenvironment: from mechanism to intervention.Theranostics · 2025Review
- Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives.Journal of hematology & oncology · 2024Review
- MDSC-derived S100A8/9 contributes to lupus pathogenesis by promoting TLR7-mediated activation of macrophages and dendritic cells.Cellular and molecular life sciences : CMLS · 2024Article
- Research progress on the role of tumor‑associated macrophages in tumor development and their use as molecular targets (Review).International journal of oncology · 2024Review
- Diverse functions of myeloid-derived suppressor cells in autoimmune diseases.Immunologic research · 2024Review
- Machine learning-based identification of an immunotherapy-related signature to enhance outcomes and immunotherapy responses in melanoma.Frontiers in immunology · 2024Article
- IFN-γ and androgens disrupt mitochondrial function in murine myocytes.The Journal of pathology · 2023Article
- Molecular Crosstalk between Chromatin Remodeling and Tumor Microenvironment in Multiple Myeloma.Current oncology (Toronto, Ont.) · 2022Review
- Howard A. Young's 4 Decades in Science: More Than Just Experiments.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 7 institutions in 2 countries.
Julio C ValenciaLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland. valencij@mail.nih.gov.
Rebecca A Erwin-CohenLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.ORCID 0000-0002-5838-9026
Paul E ClavijoHead and Neck Surgery Branch, National Institute on Deafness and other Communication Disorders, Bethesda, Maryland.
Clint AllenHead and Neck Surgery Branch, National Institute on Deafness and other Communication Disorders, Bethesda, Maryland.
Michael E SanfordLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
Chi-Ping DayLaboratory of Cancer Biology and Genetics, CCR, NCI, Bethesda, Maryland.ORCID 0000-0001-5200-2372
Megan M HessLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.ORCID 0000-0003-0055-8365
Morgan JohnsonLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
Jie YinLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
John M FenimoreLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
Ian A BettencourtLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.ORCID 0000-0001-8154-7670
Koichi TsuneyamaTokushima University Graduate School, Tokushima, Japan.
Maria E RomeroCVPath Institute, Gaithersburg, Maryland.
Kimberly D KlarmannLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
Peng JiangCancer Data Science laboratory, CCR, NCI, Bethesda, Maryland.ORCID 0000-0002-7828-5486
Heekyong R BaeLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.
Daniel W McVicarLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.ORCID 0000-0002-1112-5111
Glenn MerlinoLaboratory of Cancer Biology and Genetics, CCR, NCI, Bethesda, Maryland.
Elijah F EdmondsonMolecular Histopathology Laboratory, NCI, Frederick, Maryland.ORCID 0000-0002-6106-3705
Niroshana AnandasabapathyWeill Cornell Medicine, New York, New York.ORCID 0000-0002-0473-8358
Howard A YoungLaboratory of Cancer Immunometabolism, CCR, NCI, Frederick Maryland.ORCID 0000-0002-3118-5111
Center for Cancer Research · USCancer Genetics (United States) · USNational Institute on Deafness and Other Communication Disorders · USCornell University · USCVPath Institute · USIntermolecular (United States) · USTokushima University · JP
Funding
EXPAND PARTICIPATION BY MINORITIES IN BIOMEDICAL SCIENCER25GM055036 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI SUMMERS, MICHAEL FINLEY · 1996 to 2021
$16.9MPeripheral mechanisms of homeostasis and tolerance through skin dendritic cellsR01AR070234 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANANDASABAPATHY, NIROSHANA · 2016 to 2020
$2.6MPeripheral immune surveillance and long-lived barrier immunity through T cell DC cross-talkR56AR078686 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANANDASABAPATHY, NIROSHANA · 2021 to 2021
$649kCCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261200800001ENIAMS NIH HHS R01 AR070234NIAMS NIH HHS R56 AR078686NIGMS NIH HHS R25 GM055036
Abstract
The relationship between cancer and autoimmunity is complex. However, the incidence of solid tumors such as melanoma has increased significantly among patients with previous or newly diagnosed systemic autoimmune disease (AID). At the same time, immune checkpoint blockade (ICB) therapy of cancer induces
Indexed as
AutoimmunityAnimalsCD40 AntigensImmunotherapyInterleukin-27Lupus Erythematosus, SystemicMacrophagesMelanomaMiceMice, Inbred C57BLMice, KnockoutMyeloid-Derived Suppressor CellsTumor MicroenvironmentCD40 AntigensInterleukin-27
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.