Evidence map›Paper›PMID 34644538›Full record

ReviewCell metabolism2021

Nutrients in the fate of pluripotent stem cells.

Vivian Lu, Irena J Roy, Michael A Teitell

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. MCT1 governs a metabolic checkpoint at pachytene during spermatogenesis.bioRxiv : the preprint server for biology · 2026
    Article
  3. Review
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  8. Review
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  11. Review
  12. Article
  13. Article
  14. Molecular Insight into Iron Homeostasis of Acute Myeloid Leukemia Blasts.International journal of molecular sciences · 2023
    Article
  15. Breast cancers as ecosystems: a metabolic perspective.Cellular and molecular life sciences : CMLS · 2023
    Review
  16. Article
  17. Article
  18. Review
  19. Article
  20. Role of Diet in Stem and Cancer Stem Cells.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Vivian LuDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Irena J RoyDevelopmental and Stem Cell Biology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Michael A TeitellDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, California NanoSystems Institute, and Broad Center for Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: mteitell@mednet.ucla.edu.
California NanoSystems Institute · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
RNA trafficking in mitochondriaR01GM073981 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Carla M Koehler, MICHAEL A TEITELL · 2006 to 2026
$5.1M
SPOTs: Optical Technologies for Instantly Quantifying Multicellular Response ProfilesR01GM127985 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIOU, PEI-YU, TEITELL, MICHAEL A · 2020 to 2023
$1.7M
(PQ5) Mitochondrial Transfer in Tumor Heterogeneity and Acquired Resistence to TherapyR21CA227480 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TEITELL, MICHAEL A · 2019 to 2020
$373k
Role of pH on Lineage Fate during Pluripotent Stem Cell DifferentiationF31HD097960 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LU, VIVIAN · 2019 to 2021
$112k
NCI NIH HHS P30 CA016042NCI NIH HHS R21 CA227480NICHD NIH HHS F31 HD097960NIGMS NIH HHS R01 GM073981NIGMS NIH HHS R01 GM127985
6 · The paper itself

Abstract

Pluripotent stem cells model certain features of early mammalian development ex vivo. Medium-supplied nutrients can influence self-renewal, lineage specification, and earliest differentiation of pluripotent stem cells. However, which specific nutrients support these distinct outcomes, and their mechanisms of action, remain under active investigation. Here, we evaluate the available data on nutrients and their metabolic conversion that influence pluripotent stem cell fates. We also discuss key questions open for investigation in this rapidly expanding area of increasing fundamental and practical importance.

Indexed as

Pluripotent Stem CellsAnimalsCell DifferentiationCell LineageMammalsNutrientsNutrientsdevelopmentdifferentiationfatemetabolismnutrientspluripotent stem cell

Identifiers

PMID34644538
PMCPMC8568661
OpenAlexW3207305670

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.