ArticleNature2021
Convergent somatic mutations in metabolism genes in chronic liver disease.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 1 pooled it
22.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 1 synthesis or guideline pooled it, 187 citations in OpenAlex.
- Low liver fat in non-alcoholic steatohepatitis-related significant fibrosis and cirrhosis is associated with hepatocellular carcinoma, decompensation and mortality.Alimentary pharmacology & therapeutics · 2024Pooled it
- Inhibition of Acetylation Activity of p300/CBP Ameliorates Hepatic Steatosis Through Downregulation of ACSL4.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- A single-cell lens into the co-evolution of genotypes and phenotypes in cancer.Nature reviews. Cancer · 2026Review
- Genetic and genomic insights across the steatotic liver disease spectrum.Clinical and molecular hepatology · 2026Review
- The Emerging Challenge of Non-Cirrhotic MASLD-Related Hepatocellular Carcinoma: Etiology, Immunopathology, and Precision Oncology.Liver cancer · 2026Review
- Genetic testing in liver diseases: Clinical applications.JHEP reports : innovation in hepatology · 2026Review
- [Proportion and clinical characteristics of probable metabolic-associated fatty liver disease-related cirrhosis in cryptogenic cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Article
- Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity.Nature communications · 2026Article
- Understanding the somatic evolution of metabolic traits.Nature metabolism · 2026Article
- Beyond Fat: Reframing MASLD Through Genetics, Clonal Biology, and Precision Hepatology.Pharmaceuticals (Basel, Switzerland) · 2026Review
- GPAM mediates mitochondrial dysfunction and the progression of alcoholic liver disease through lipid remodeling.Science advances · 2026Article
- Article
- Effects of ethanol and acetaldehyde on multi-organ genomic mutation landscapes.Cell biology and toxicology · 2026Article
- Current Understanding of CHIP's Immunobiological Footprint with A Focus on Gastrointestinal Disorders: A Review of the Literature.Current oncology reports · 2026Review
- Age distinguishes selection from causation in cancer genomes.Nature genetics · 2026Article
- Germline mutations and somatic mosaicism in steatotic liver diseases and related liver carcinogenesis.Nature reviews. Gastroenterology & hepatology · 2026Review
- Article
- Mutational signature-based classification uncovers emerging oral cancer subtypes with distinct molecular patterns.International journal of oral science · 2026Article
- The cost of cure: cancer therapies sculpt somatic evolution and signaling landscapes in normal tissues.Signal transduction and targeted therapy · 2026Article
- Genotype-to-Phenotype Mapping of Somatic Clonal Mosaicism via Single-Cell Co-Capture of DNA Mutations and mRNA Transcripts.Cancer discovery · 2026Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors at 5 institutions in 2 countries.
Stanley W K NgCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Foad J RouhaniCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Simon F BrunnerCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5935-6189
Natalia BrzozowskaCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Sarah J AitkenCRUK Cambridge Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-1897-4140
Ming YangMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Federico AbascalCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-6201-1587
Luiza MooreCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5315-516X
Efterpi NikitopoulouMRC Cancer Unit, University of Cambridge, Cambridge, UK.
Lia ChappellCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Daniel LeongamornlertCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-3486-3168
Aleksandra IvovicCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Philip RobinsonCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-6237-7159
Timothy ButlerCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-5803-1035
Mathijs A SandersCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Nicholas WilliamsCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-3989-9167
Tim H H CoorensCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5826-3554
Jon TeagueCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Keiran RaineCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-5634-1539
Adam P ButlerCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Yvette HooksCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Beverley WilsonCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Natalie BirtchnellCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.
Huw NaylorDepartment of Surgery, Addenbrooke's Hospital, Cambridge, UK.ORCID http://orcid.org/0000-0001-8264-8596
Susan E DaviesDepartment of Pathology, Addenbrooke's Hospital, Cambridge, UK.
Michael R StrattonCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0001-6035-153X
Iñigo MartincorenaCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0003-1122-4416
Raheleh RahbariCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK.ORCID http://orcid.org/0000-0002-1839-7785
Christian FrezzaMRC Cancer Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-3293-7397
Matthew HoareCRUK Cambridge Institute, Cambridge, UK. Matthew.Hoare@cruk.cam.ac.uk.ORCID http://orcid.org/0000-0001-5990-9604
Peter J CampbellCancer Genome Project, Wellcome Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.ORCID http://orcid.org/0000-0002-3921-0510
Wellcome Sanger Institute · GBUniversity of Cambridge · GBAddenbrooke's Hospital · GBErasmus MC · NLWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
Cancer Research UK 19924Cancer Research UK 21777Cancer Research UK 26813Cancer Research UK 27114Cancer Research UK 29681Medical Research Council MC_UP_1101/3Medical Research Council MC_UU_12022/6Wellcome Trust
Abstract
The progression of chronic liver disease to hepatocellular carcinoma is caused by the acquisition of somatic mutations that affect 20-30 cancer genes
Indexed as
Active Transport, Cell NucleusApoptosis Regulatory ProteinsCell Line, TumorChronic DiseaseCohort StudiesFatty Acids, NonesterifiedFemaleForkhead Box Protein O1HumansInsulin ResistanceLiverLiver DiseasesLiver Diseases, AlcoholicMaleMutationNon-alcoholic Fatty Liver DiseaseApoptosis Regulatory ProteinsCIDEB protein, humanFatty Acids, NonesterifiedForkhead Box Protein O1FOXO1 protein, humanTriglycerides
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.