Evidence map›Paper›PMID 34646120›Full record

ArticleFrontiers in molecular neuroscience2021

PRDM12 Is Transcriptionally Active and Required for Nociceptor Function Throughout Life.

Tomislav Kokotović, Michiel Langeslag, Ewelina M Lenartowicz, John Manion, Christopher W Fell, Elham Alehabib, Abbas Tafakhori, Hossein Darvish, Eric J Bellefroid, G Gregory Neely and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A compendium of validated pain genes.WIREs mechanisms of disease · 2022
    Review
  6. Article
  7. PRDM12 in Health and Diseases.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 5 countries.

Tomislav KokotovićLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Michiel LangeslagDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Ewelina M LenartowiczLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
John ManionCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.
Christopher W FellLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
Elham AlehabibStudent Research Committee, Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abbas TafakhoriIranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Hossein DarvishNeuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
Eric J BellefroidULB Neuroscience Institute (UNI), Université Libre de Bruxelles (ULB), Gosselies, Belgium.
G Gregory NeelyCharles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, Centenary Institute, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW, Australia.
Michaela KressDepartment of Physiology and Medical Physics, Institute of Physiology, Medical University of Innsbruck, Innsbruck, Austria.
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences, VBC - Vienna BioCenter, Vienna, Austria.
Vanja NagyLudwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria.
CeMM Research Center for Molecular Medicine · ATCentenary Institute · AUInnsbruck Medical University · ATAustrian Academy of Sciences · ATGolestan University · IRLudwig Boltzmann Institute for Rare and Undiagnosed Diseases · ATShahid Beheshti University of Medical Sciences · IRTehran University of Medical Sciences · IRUniversité Libre de Bruxelles · BE

Funding

Austrian Science Fund FWF P 32924
6 · The paper itself

Abstract

PR domain-containing member 12 (PRDM12) is a key developmental transcription factor in sensory neuronal specification and survival. Patients with rare deleterious variants in

Indexed as

capsaicinCIPdorsal root ganglianociceptionpainPrdm12TRPV1

Identifiers

PMID34646120
PMCPMC8502974
OpenAlexW3203862576

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.