ArticleFrontiers in cellular neuroscience2021
Neural Burst Firing and Its Roles in Mental and Neurological Disorders.
Article in Frontiers in cellular neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed.
- A prefrontal cortex-piriform cortex circuit mediates diminished interest.Molecular psychiatry · 2026Article
- Distributed burst firing mediates optimized cortical encoding of natural self-motion.Science advances · 2026Article
- Two-factor synaptic plasticity enables memory consolidation during neuronal burst firing.PNAS nexus · 2026Article
- Cellular properties and axonal projections of thyrotropin-releasing hormone-expressing neurons in the mouse lateral hypothalamic area.Journal of neurophysiology · 2026Article
- Electrophysiological Characterization of Murine Vestibular Efferent Neurons and Modulation by Acute Peripheral Vestibular Deprivation.Neuroscience bulletin · 2026Article
- Burst firing creates an attractor in synaptic weight dynamics.PLoS computational biology · 2026Article
- Chemical multiplexing in the nervous system: molecular architecture, functional stratification, and pathophysiological plasticity of neuropeptide-classical neurotransmitter cotransmission.Frontiers in molecular neuroscience · 2026Review
- NMDA receptors are not necessary for burst firing of lateral habenula neurons in mice.Frontiers in psychiatry · 2026Article
- A novel theory of rapid eye movement sleep as an integral component of the seasonal timekeeping apparatus.Frontiers in neuroscience · 2026Article
- Special Issue "Ion Channels as a Therapeutic Target: Drug Design and Pharmacological Investigation 2.0.International journal of molecular sciences · 2025Article
- Noise-Induced Hearing Loss Enhances CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling.PLoS computational biology · 2025Article
- Aberrant neuronal firing: a paracrine route to glioblastoma expansion.Cell communication and signaling : CCS · 2025Article
- Burst firing optimizes invariant coding of natural communication signals by electrosensory neural populations.iScience · 2025Article
- The molecular clock drives motivated locomotion and time-of-day-dependent firing patterns in mouse dopaminergic neurons.Npj biological timing and sleep · 2025Article
- Local activation of CB1 receptors by synthetic and endogenous cannabinoids dampens burst firing mode of reticular thalamic nucleus neurons in rats under ketamine anesthesia.Experimental brain research · 2024Article
- The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model.Cognitive neurodynamics · 2024Article
- State-Dependent Blockade of Dorsal Root Ganglion Voltage-Gated NaInternational journal of molecular sciences · 2024Article
- Comparison of alterations in local field potentials and neuronal firing in mouse M1 and CA1 associated with central fatigue induced by high-intensity interval training and moderate-intensity continuous training.Frontiers in neuroscience · 2024Article
- Predation cues induce predator specific changes in olfactory neurons encoding defensive responses in agile frog tadpoles.PloS one · 2024Article
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Authors and funding
5 authors.
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Abstract
Neural firing patterns are critical for specific information coding and transmission, and abnormal firing is implicated in a series of neural pathologies. Recent studies have indicated that enhanced burst firing mediated by T-type voltage-gated calcium channels (T-VGCCs) in specific neuronal subtypes is involved in several mental or neurological disorders such as depression and epilepsy, while suppression of T-VGCCs relieve related symptoms. Burst firing consists of groups of relatively high-frequency spikes separated by quiescence. Neurons in a variety of brain areas, including the thalamus, hypothalamus, cortex, and hippocampus, display burst firing, but the ionic mechanisms that generating burst firing and the related physiological functions vary among regions. In this review, we summarize recent findings on the mechanisms underlying burst firing in various brain areas, as well as the roles of burst firing in several mental and neurological disorders. We also discuss the ion channels and receptors that may regulate burst firing directly or indirectly, with these molecules highlighted as potential intervention targets for the treatment of mental and neurological disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.