Evidence map›Paper›PMID 34646384›Full record

ArticleTheranostics2021

Glycoproteome remodeling in MLL-rearranged B-cell precursor acute lymphoblastic leukemia.

Tiago Oliveira, Mingfeng Zhang, Eun Ji Joo, Hisham Abdel-Azim, Chun-Wei Chen, Lu Yang, Chih-Hsing Chou, Xi Qin, Jianjun Chen, Kathirvel Alagesan and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Tiago OliveiraInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Mingfeng ZhangDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Eun Ji JooDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Hisham Abdel-AzimDivision of Hematology/Oncology and Bone Marrow Transplant, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Chun-Wei ChenDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Lu YangDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Chih-Hsing ChouDivision of Hematology/Oncology and Bone Marrow Transplant, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Xi QinDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Jianjun ChenDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Kathirvel AlagesanInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Andreia AlmeidaInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Francis JacobGlyco-Oncology, Ovarian Cancer Research, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Nicolle H PackerInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Mark von ItzsteinInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Nora HeisterkampDepartment of Systems Biology, Beckman Research Institute City of Hope, Monrovia, CA, USA.
Daniel KolarichInstitute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.
Beckman Research InstituteGriffith University · AUChildren's Hospital of Los Angeles · USCity of Hope · USUniversity Hospital of Basel · CH

Funding

Targeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8M
Combinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage LeukemiaR37CA233691 · NCI · MAYO CLINIC ROCHESTER · PI CHEN, CHUN-WEI DAVID · 2019 to 2025
$2.8M
The role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2019 to 2023
$2.3M
Targeting TET1 signaling to treat acute myeloid leukemiaR01CA211614 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.3M
The function and underlying mechanism of TET1 in myelodysplastic syndromesR01DK124116 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2023
$2.2M
The role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1M
NCI NIH HHS R01 CA211614NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA243386NCI NIH HHS R37 CA233691NIDDK NIH HHS R01 DK124116
6 · The paper itself

Abstract

B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with mixed-lineage leukemia gene rearrangement (MLL-r) is a poor-prognosis subtype for which additional therapeutic targets are urgently needed. Currently no multi-

Indexed as

Cell Line, TumorGene ExpressionGene Expression ProfilingGene Expression Regulation, LeukemicGene RearrangementGlycomicsHistone-Lysine N-MethyltransferaseHumansLeukemia, Biphenotypic, AcuteOncogene Proteins, FusionPrecursor B-Cell Lymphoblastic Leukemia-LymphomaPrecursor Cell Lymphoblastic Leukemia-LymphomaProteomicsTranscriptomeHistone-Lysine N-MethyltransferaseOncogene Proteins, FusionGlycomicsLeukemiamulti-omicsProteomicsTranscriptomics

Identifiers

PMID34646384
PMCPMC8490503
OpenAlexW3205499276

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.