Evidence map›Paper›PMID 34646532›Full record

ArticleFood science & nutrition2021

Protective effects of tea extracts against alcoholic fatty liver disease in mice via modulating cytochrome P450 2E1 expression and ameliorating oxidative damage.

Bang-Yan Li, Qian-Qian Mao, Ren-You Gan, Shi-Yu Cao, Xiao-Yu Xu, Min Luo, Hang-Yu Li, Hua-Bin Li

Open access · hybridAbstract read
In one paragraph

Article in Food science & nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Improvement effect of Biluochun tea active extract on CClFood science and biotechnology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. A Review: Cytochrome P450 in Alcoholic and Non-Alcoholic Fatty Liver Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Mitochondrial Dysfunction and Chronic Liver Disease.Current issues in molecular biology · 2022
    Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Bang-Yan LiGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.ORCID https://orcid.org/0000-0001-7446-2505
Qian-Qian MaoGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.ORCID https://orcid.org/0000-0003-3332-2922
Ren-You GanResearch Center for Plants and Human Health Institute of Urban Agriculture Chinese Academy of Agricultural Sciences Chengdu China.
Shi-Yu CaoGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.
Xiao-Yu XuGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.
Min LuoGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.
Hang-Yu LiGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.
Hua-Bin LiGuangdong Provincial Key Laboratory of Food, Nutrition and Health Department of Nutrition School of Public Health Sun Yat-Sen University Guangzhou China.ORCID https://orcid.org/0000-0003-2332-8554
Sun Yat-sen University · CNChinese Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alcoholic fatty liver disease (AFLD) has been a severe public health problem. Oxidative stress is involved in the initiation and progression of AFLD. Tea is a popular beverage worldwide with strong antioxidant activity. In this research, our purpose is to explore and compare the effects of 12 selected teas on AFLD. The ethanol liquid diet was used to feed the mice, and 12 tea extracts were administrated at 200 mg/kg body weight every day for 4 weeks. The results showed that the application of several tea extracts exhibited different inhibitory effects on lipid accumulation induced by sub-acute alcohol consumption based on the determination of triglyceride concentration and the histological alteration in the liver. In addition, several teas significantly decreased serum alanine aminotransferase and aspartate aminotransferase activities, inhibited the cytochrome P450 2E1 expression, and promoted alcohol metabolism (

Indexed as

alcoholic fatty liver diseasealcohol metabolismantioxidant activitylipid accumulationtea

Identifiers

PMID34646532
PMCPMC8498066
OpenAlexW3196735613

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.