ArticleAmerican journal of translational research2021
The effects of alprostadil combined with α-lipoic acid in the treatment of senile diabetic nephropathy.
Article in American journal of translational research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 6 citations in OpenAlex.
- Alpha-lipoic Acid: An Antioxidant with Anti-aging Properties for Disease Therapy.Current medicinal chemistry · 2025Review
- Efficacy and Mechanism of Alprostadil in Diabetes Mellitus Combined with Peripheral Atherosclerosis.Anatolian journal of cardiology · 2024Article
- Alpha-lipoic acid: A promising pharmacotherapy seen through the lens of kidney diseases.Current research in pharmacology and drug discovery · 2024Review
- Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine.Frontiers in pharmacology · 2023Review
- Efficacy of epalrestat combined with alprostadil for diabetic nephropathy and its impacts on renal fibrosis and related factors of inflammation and oxidative stress.American journal of translational research · 2022Article
- Expression of Ferroptosis-Related Genes is Correlated with Immune Microenvironment in Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the clinical efficacy of alprostadil combined with α-Lipoic acid (α-LA) in the treatment of senile diabetic nephropathy (SDN) and the combination's effect on the serum chemerin and neutrophil gelatinase-associated lipocalin (NGAL) expressions.
methodsSeventy-six patients with diabetic nephropathy (DN) admitted to our hospital from March 2018 to October 2019 were recruited as the research cohort. Among them, 36 patients who were administered alprostadil monotherapy were placed in the control group (CG), and the remaining 40 patients administered α-LA in addition to the alprostadil were placed in the research group (RG). The treatment effectiveness rate, the incidence of adverse reactions, and the changes in the renal function indexes (BUN, SCr, UAER) and the blood glucose indexes (FPG, 2hPG) were compared between the two groups.
resultsThe total effective rate in the RG was significantly higher than the total effective rate in the CG (P < 0.05). The renal function and blood glucose indexes dropped significantly after the treatment (P < 0.001). The chemerin and NGAL levels were significantly reduced in both groups after the treatment (P < 0.05), and the chemerin and NGAL expressions in the RG were significantly lower than they were in the CG (P < 0.05).
conclusionAlprostadil combined with α-LA is better than alprostadil monotherapy in the treatment of DN because it can improve the effectiveness rate, reduce the blood glucose, and improve the renal function while effectively reducing patients' serum chemerin and NGAL levels.
Indexed as
Identifiers
34650761PMC8507045W3206784984What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.