Evidence map›Paper›PMID 34651095›Full record

ArticleJCO precision oncology2021

Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an

Ross Mangum, Jacquelyn Reuther, Kelsey C Bertrand, Raghu Chandramohan, Marcia K Kukreja, Arnold C Paulino, Donna Muzny, Jianhong Hu, Richard A Gibbs, Daniel J Curry and 9 more

Abstract readCase Reports
In one paragraph

Article in JCO precision oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. TRK inhibitors in pediatric gliomas.Neuro-oncology advances · 2026
    Review
  2. Review
  3. Clinical Characteristics and Outcomes of Central Nervous System Tumors Harboring NTRK Gene Fusions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  4. Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ross MangumDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-2288-042X
Jacquelyn ReutherDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX.
Kelsey C BertrandDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Raghu ChandramohanDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Marcia K KukrejaDepartment of Radiology, Texas Children's Hospital, Houston, TX.ORCID 0000-0001-8902-5236
Arnold C PaulinoDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX.
Donna MuznyDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Jianhong HuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Richard A GibbsDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-1356-5698
Daniel J CurryDivision of Pediatric Neurosurgery, Department of Neurosurgery, Baylor College of Medicine, Houston, TX.
Fatema MalbariDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Murali M ChintagumpalaDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Adekunle M AdesinaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX.
Kevin E FisherDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-6179-0937
Stephen C MackDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Sharon E PlonDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-9626-0936
Angshumoy RoyDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
D Williams ParsonsDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Frank Y LinDepartment of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Brain NeoplasmsChildEpendymomaGene Expression ProfilingHumansMaleMembrane GlycoproteinsNeoplasm Recurrence, LocalPyrazolesPyrimidinesReceptor, trkBlarotrectinibMembrane GlycoproteinsPyrazolesPyrimidinesReceptor, trkBtropomyosin-related kinase-B, human

Identifiers

PMID34651095
PMCPMC8509924

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.