Evidence map›Paper›PMID 34653252›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2022

Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.

Richard J Auchus, Kyriakie Sarafoglou, Patricia Y Fechner, Maria G Vogiatzi, Erik A Imel, Shanlee M Davis, Nagdeep Giri, Julia Sturgeon, Eiry Roberts, Jean L Chan and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial, Phase II
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03525886 (A Phase 2, Open-Label, Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adult Subjects With Congenital Adrenal Hyperplasia), which is not on this map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03525886 phase2completednot on this map

A Phase 2, Open-Label, Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NBI-74788 in Adult Subjects With Congenital Adrenal Hyperplasia

TypeinterventionalSponsorNeurocrine BiosciencesRan2018 to 2020Enrolled18ConditionsCAH - Congenital Adrenal HyperplasiaArmsNBI-74788
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

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  6. [Congenital adrenal hyperplasia].Problemy endokrinologii · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Richard J AuchusDepartments of Pharmacology and Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-6815-6181
Kyriakie SarafoglouDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID 0000-0002-5741-3629
Patricia Y FechnerDepartment of Pediatrics, Division of Pediatric Endocrinology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
Maria G VogiatziDivision of Endocrinology, Children's Hospital of Philadelphia , Philadelphia, Pennsylvania, USA.
Erik A ImelDepartments of Medicine and Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-7284-3467
Shanlee M DavisDepartment of Pediatrics, Section of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Nagdeep GiriNeurocrine Biosciences Inc, San Diego, California, USA.
Julia SturgeonNeurocrine Biosciences Inc, San Diego, California, USA.
Eiry RobertsNeurocrine Biosciences Inc, San Diego, California, USA.
Jean L ChanNeurocrine Biosciences Inc, San Diego, California, USA.
Robert H FarberNeurocrine Biosciences Inc, San Diego, California, USA.
Neurocrine Biosciences (United States) · USChildren's Hospital of Philadelphia · USIndiana University School of MedicineSeattle Children's Hospital · USUniversity of Colorado Denver · USUniversity of Michigan · USUniversity of Minnesota Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextClassic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) is characterized by impaired cortisol synthesis and excess androgen production. Corticotropin-releasing factor type 1 receptor (CRF1R) antagonism may decrease adrenal androgen production.

objectiveThis work aimed to evaluate the safety, tolerability, and efficacy of crinecerfont (NBI-74788), a selective CRF1R antagonist, in 21OHD.

methodsThis open-label, phase 2 study, with sequential cohort design (NCT03525886), took place in 6 centers in the United States. Participants included men and women, aged 18 to 50 years, with 21OHD. Interventions included 4 crinecerfont regimens, each administered orally for 14 consecutive days: 50 or 100 mg once daily at bedtime (cohorts 1 and 2, respectively); 100 mg once daily in the evening (cohort 3); and 100 mg twice daily (cohort 4). Participants could enroll in more than 1 cohort. Main outcomes included changes from baseline to day 14 in adrenocorticotropin (ACTH), 17-hydroxyprogesterone (17OHP), androstenedione, and testosterone.

resultsEighteen participants (11 women, 7 men) were enrolled: cohort 1 (n = 8), cohort 2 (n = 7), cohort 3 (n = 8), cohort 4 (n = 8). Mean age was 31 years; 94% were White. Median percent reductions were more than 60% for ACTH (-66%), 17OHP (-64%), and androstenedione (-64%) with crinecerfont 100 mg twice a day. In female participants, 73% (8/11) had a 50% or greater reduction in testosterone levels; male participants had median 26% to 65% decreases in androstenedione/testosterone ratios.

conclusionCrinecerfont treatment for 14 days lowered ACTH and afforded clinically meaningful reductions of elevated 17OHP, androstenedione, testosterone (women), or androstenedione/testosterone ratio (men) in adults with 21OHD. Longer-term studies are required to evaluate the effects of crinecerfont on clinical end points of disordered steroidogenesis and glucocorticoid exposure in patients with 21OHD.

Indexed as

Adrenal Hyperplasia, CongenitalAzabicyclo CompoundsOxadiazolesReceptors, Corticotropin-Releasing Hormone17-alpha-HydroxyprogesteroneAdministration, OralAdolescentAdrenocorticotropic HormoneAdultAminesAndrostenedioneBiomarkersCRF Receptor, Type 1Dose-Response Relationship, DrugFemaleHumans17-alpha-HydroxyprogesteroneAdrenocorticotropic HormoneAminesAndrostenedioneAzabicyclo CompoundsBiomarkersCRF Receptor, Type 1crinecerfontNBI 77860OxadiazolesReceptors, Corticotropin-Releasing HormoneTestosteroneThiazoles17-hydroxyprogesterone21-hydroxylase deficiencycongenital adrenal hyperplasiacrinecerfontNBI-74788

Identifiers

PMID34653252
PMCPMC8851935
OpenAlexW3206029402

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.