ArticleEuropean geriatric medicine2018
Association between allopurinol use and Parkinson's disease in older adults.
Article in European geriatric medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Serendipitous Symptom Control: Allopurinol for Spasticity in a Case of SPG4-Linked Hereditary Spastic Paraplegia-A Case Report.Clinical case reports · 2026Article
- Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective.Neuropsychopharmacology reports · 2024Review
- Elevated Serum Xanthine Oxidase and Its Correlation with Antioxidant Status in Patients with Parkinson's Disease.Biomolecules · 2024Article
- Identification of Drugs Associated with Lower Risk of Parkinson's Disease Using a Systematic Screening Approach in a Nationwide Nested Case-Control Study.Clinical epidemiology · 2022Article
- Advances in Proteomic and Metabolomic Profiling of Neurodegenerative Diseases.Frontiers in neurology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLittle evidence is available about the association between allopurinol use and Parkinson's disease. The present study aimed to explore the association between allopurinol use and Parkinson's disease in older adults in Taiwan.
methodsWe conducted a population-based case-control study using the database of the Taiwan National Health Insurance Program. In total, 4399 subjects aged ≥ 65 years with newly diagnosed Parkinson's disease between 2000 and 2013 were included as the cases. Additionally, 4399 subjects aged ≥ 65 years without Parkinson's disease were randomly selected as the controls. Both cases and controls were matched for age and comorbidities. Ever use of allopurinol was defined as subjects who had at least a prescription for allopurinol before the index date, whereas never use of allopurinol was defined as those who never had a prescription for allopurinol before the index date. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) for the association between allopurinol use and Parkinson's disease.
resultsThe OR of Parkinson's disease was 0.93 for subjects with ever use of allopurinol (95% CI 0.82, 1.04), compared with never use.
conclusionsNo association can be detected between allopurinol use and Parkinson's disease in older adults in Taiwan.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.