ReviewJournal of neurodevelopmental disorders2021
Pre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda.
Review in Journal of neurodevelopmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Parent-Mediated Interventions for ASD Under 3 Years: A Systematic Review, Meta Analysis, and Moderator Analyses.Journal of autism and developmental disorders · 2026Pooled it
- Examining Behavioral Interventions for Infancy and Early Toddlerhood: A Systematic Review of Intervention Effects, Parameters, and Participants.Journal of autism and developmental disorders · 2026Pooled it
- Infant Achievements Intervention Improves Caregiver Implementation Fidelity and Infant Social Communication Outcomes: A Preliminary Randomized Clinical Trial.Autism research : official journal of the International Society for Autism Research · 2025Trial
- Dyscoordination of thalamic reticular spindles is associated with social memory deficits in mice and humans with autism spectrum disorder.Nature communications · 2026Article
- Converging neurotrophic-immune signaling in autism spectrum disorder: integrative roles of klotho, GDNF/GFRA-1, IGF-1 and GLP-1 pathways.Metabolic brain disease · 2026Review
- Subclinical neuropsychiatric trait variation in parents of children with autism spectrum disorder: a cohort study.Molecular autism · 2026Article
- Predicting Autism Spectrum Disorder in Children Using Glowworm Optimization With Extreme Learning Machine Networks.Brain and behavior · 2026Article
- Manual and automated assessments of general movements in neonates are associated with early autism risk at 18 months.Scientific reports · 2026Article
- From risk to resilience: a narrative overview of modifiable factors influencing anxiety in children with autism spectrum disorder (part II).Frontiers in psychiatry · 2026Review
- Latent trajectories of early social communication development are associated with autism diagnosis and language outcomes.Frontiers in child and adolescent psychiatry · 2026Article
- Does baseline language ability predict response to early intervention for toddlers with early signs of autism? Evidence from a caregiver-mediated program.Frontiers in human neuroscience · 2026Article
- Anticipation of a therapeutic odyssey following predictive testing for autism.Scientific reports · 2025Article
- Caregiver Perspectives on Telehealth Assessment and Other Supports for Infants with Early Developmental Concerns.Journal of autism and developmental disorders · 2025Article
- Sensory and cognitive awareness impairment patterns in children with autism spectrum disorder: a factorial analysis of the underlying constructs.Child and adolescent psychiatry and mental health · 2025Article
- A Longitudinal Transdisciplinary Approach for Autism Spectrum Disorder.Children (Basel, Switzerland) · 2025Article
- "Now I have to act on that": Parent anticipation of a therapeutic odyssey following predictive testing for autism.Research square · 2025Article
- Should newborn genetic testing for autism be introduced?Journal of medical ethics · 2025Article
- Pupil responses to social stimuli are associated with adaptive behaviors across the first 24 months of life.Journal of neurodevelopmental disorders · 2025Article
- Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.Journal of neurodevelopmental disorders · 2025Article
- How will developmental neuroimaging contribute to the prediction of neurodevelopmental or psychiatric disorders? Challenges and opportunities.Developmental cognitive neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 10 institutions in 2 countries.
Funding
Abstract
Autism spectrum disorder (ASD) impacts an individual's ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identification of ASD with significant progress being made in understanding the early behavioral and biological markers that precede a diagnosis, providing a catalyst for pre-symptomatic identification and intervention. Evidence from preclinical trials suggest that intervention prior to the onset of ASD symptoms may yield more improved developmental outcomes, and clinical studies suggest that the earlier intervention is administered, the better the outcomes. This article brings together a multidisciplinary group of experts to develop a conceptual framework for behavioral intervention, during the pre-symptomatic period prior to the consolidation of symptoms into diagnosis, in infants at very-high-likelihood for developing ASD (VHL-ASD). The overarching goals of this paper are to promote the development of new intervention approaches, empirical research, and policy efforts aimed at VHL-ASD infants during the pre-symptomatic period (i.e., prior to the consolidation of the defining features of ASD).
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.