Evidence map›Paper›PMID 34657184›Full record

ArticleEuropean journal of nutrition2022

Parental high-fat high-sugar diet programming and hypothalamus adipose tissue axis in male Wistar rats.

Helena César, Marcela Nascimento Sertorio, Esther Alves de Souza, Giovana Jamar, Aline Santamarina, Andrea Jucá, Breno Picin Casagrande, Luciana Pellegrini Pisani

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Paternal and/or Maternal Blackberry (Antioxidants (Basel, Switzerland) · 2025
    Article
  4. Review
  5. Article
  6. Article
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  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Helena CésarPrograma de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo-UNIFESP, Santos, SP, Brazil.
Marcela Nascimento SertorioPrograma de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Esther Alves de SouzaPrograma de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Giovana JamarDepartamento de Biociências, Universidade Federal de São Paulo, Silva Jardim, 136. Laboratório 311, 3° andar, Vila Mathias, Santos, SP, 11015-020, Brazil.
Aline SantamarinaDepartamento de Biociências, Universidade Federal de São Paulo, Silva Jardim, 136. Laboratório 311, 3° andar, Vila Mathias, Santos, SP, 11015-020, Brazil.
Andrea JucáDepartamento de Biociências, Universidade Federal de São Paulo, Silva Jardim, 136. Laboratório 311, 3° andar, Vila Mathias, Santos, SP, 11015-020, Brazil.
Breno Picin CasagrandeDepartamento de Biociências, Universidade Federal de São Paulo, Silva Jardim, 136. Laboratório 311, 3° andar, Vila Mathias, Santos, SP, 11015-020, Brazil.
Luciana Pellegrini PisaniDepartamento de Biociências, Universidade Federal de São Paulo, Silva Jardim, 136. Laboratório 311, 3° andar, Vila Mathias, Santos, SP, 11015-020, Brazil. lucianapisani@gmail.com.ORCID http://orcid.org/0000-0001-6579-6167
Universidade Federal de São Paulo · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico FellowshipFundação de Amparo à Pesquisa do Estado de São Paulo 2017/09646-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2019/09724-8
6 · The paper itself

Abstract

purposeMaternal nutrition during early development and paternal nutrition pre-conception can programme offspring health status. Hypothalamus adipose axis is a target of developmental programming, and paternal and maternal high-fat, high-sugar diet (HFS) may be an important factor that predisposes offspring to develop obesity later in life. This study aims to investigate Wistar rats' maternal and paternal HFS differential contribution on the development, adiposity, and hypothalamic inflammation in male offspring from weaning until adulthood.

methodsMale progenitors were fed a control diet (CD) or HFS for 10 weeks before mating. After mating, dams were fed CD or HFS only during pregnancy and lactation. Forming the following male offspring groups: CD-maternal and paternal CD; MH-maternal HFS and paternal CD; PH-maternal CD and paternal HFS; PMH-maternal and paternal HFS. After weaning, male offspring were fed CD until adulthood.

resultsMaternal HFS diet increased weight, visceral adiposity, and serum total cholesterol levels, and decreased hypothalamic weight in weanling male rats. In adult male offspring, maternal HFS increased weight, glucose levels, and hypothalamic NFκBp65. Paternal HFS diet lowered hypothalamic insulin receptor levels in weanling offspring and glucose and insulin levels in adult offspring. The combined effects of maternal and paternal HFS diets increased triacylglycerol, leptin levels, and hypothalamic inflammation in weanling rats, and increased visceral adiposity in adulthood.

conclusionMale offspring intake of CD diet after weaning reversed part of the effects of parental HFS diet during the perinatal period. However, maternal and paternal HFS diet affected adiposity and hypothalamic inflammation, which remained until adulthood.

Indexed as

Prenatal Exposure Delayed EffectsSugarsAdipose TissueAdiposityAnimalsDiet, High-FatFemaleHumansHypothalamusLactationMaleMaternal Nutritional Physiological PhenomenaPregnancyRatsRats, WistarSugarsAdiposityDevelopmental programmingHigh-fat high-sugar dietHypothalamic inflammationLow-grade inflammationPaternal diet

Identifiers

PMID34657184
OpenAlexW3207432494

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.