Evidence mapPaperPMID 34662221Full record

ArticleAssay and drug development technologies

A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators

Hunter G Larson, Alexey V Zakharov, Sukumar Sarkar, Shyh-Ming Yang, Ganesha Rai, James M Larner, Anton Simeonov, Natalia J Martinez

Open access · greenAbstract read
In one paragraph

Article in Assay and drug development technologies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. HiBiT Cellular Thermal Shift Assay (HiBiT CETSA).Methods in molecular biology (Clifton, N.J.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Hunter G LarsonNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Alexey V ZakharovNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.ORCID 0000-0003-2466-1711
Sukumar SarkarDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Shyh-Ming YangNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.ORCID 0000-0003-1928-136X
Ganesha RaiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.ORCID 0000-0001-9763-9641
James M LarnerDepartment of Radiation Oncology, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Anton SimeonovNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Natalia J MartinezNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
National Institutes of Health · USUniversity of Virginia · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Estrogen Receptor alphaHigh-Throughput Screening AssaysBiological AssayHumansMCF-7 CellsEstrogen Receptor alphaCETSAERαHiBiTqHTS

Identifiers

PMID34662221
PMCPMC8713567
OpenAlexW3207464131

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.