Evidence map›Paper›PMID 34666235›Full record

ArticleCytokine2022

Host characteristics associated with serologic inflammatory biomarkers in women.

Sophia S Wang, Charlie Zhong, Marta Epeldegui, Sarah Nunes, Larry Magpantay, Jessica Clague DeHart, Susan Hurley, Debbie Goldberg, Elena Martinez, James V Lacey and 2 more

Open access · greenAbstract read
In one paragraph

Article in Cytokine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Sophia S WangDivision of Health Analytics, City of Hope, Duarte, CA, USA. Electronic address: sowang@coh.org.
Charlie ZhongEugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA.
Marta EpeldeguiUniversity of California, Los Angeles, CA, USA.
Sarah NunesEugene and Ruth Roberts Academy, City of Hope, Duarte, CA, USA; Chapman University, Orange, CA, USA.
Larry MagpantayUniversity of California, Los Angeles, CA, USA.
Jessica Clague DeHartClaremont College, Claremont, CA, USA.
Susan HurleyUniversity of California San Francisco, CA, USA; Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, CA, USA.
Debbie GoldbergUniversity of California San Francisco, CA, USA.
Elena MartinezUniversity of California San Diego, CA, USA.
James V LaceyDivision of Health Analytics, City of Hope, Duarte, CA, USA.
Otoniel Martinez-MazaUniversity of California, Los Angeles, CA, USA.
Peggy ReynoldsUniversity of California San Francisco, CA, USA.
University of California, Los Angeles · USUniversity of California, San Francisco · USCity of Hope · USCity Of Hope National Medical Center · USClaremont Colleges · USUniversity of California San Diego · US

Funding

VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DIANE M SIMEONE · 1985 to 2026
$124.9M
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
CALIFORNIA TEACHERS STUDYR01CA077398 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BERNSTEIN, LESLIE · 1998 to 2014
$29.7M
Oil and Gas as Drivers of Climate Change and Health: Developing unique resources to investigate multi-level and diverse effects of exposure to oil and gas wellsU01CA199277 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V, MARTINEZ, MARIA ELENA · 2015 to 2024
$20.7M
UCSF Environmental Research and Translation for Health Center (EaRTH Center)P30ES030284 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rashmi Joglekar · 2020 to 2026
$11.2M
New Biospecimens to Enhance Research in the California Teachers Study CohortUM1CA164917 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI LACEY, JAMES V · 2012 to 2015
$10.1M
Sleep and Cancer: Evaluation of Risk and Insights into MechanismsR01CA207020 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REYNOLDS, PEGGY · 2017 to 2020
$2.3M
NCI NIH HHS P30 CA023100NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA207020NCI NIH HHS U01 CA199277NCI NIH HHS UM1 CA164917NIEHS NIH HHS P30 ES030284
6 · The paper itself

Abstract

backgroundThere is growing evidence that exposure to low-grade inflammation may be associated with adverse health outcomes.

methodsWe conducted a cross-sectional study within the California Teachers Study prospective cohort, among female participants who had completed a questionnaire that asked about their health behaviors (e.g., diabetes, physical activity, body mass index, medication use) and who had donated blood within a year of their questionnaire. 822 women with stored serum were evaluated for 16 immune biomarkers. In addition, four immune pathways were constructed: Th1, pro-inflammatory/macrophage activation, B-cell activation, and T-cell activation. Odds ratios (ORs) and 95% confidence intervals (CI) for the association between host characteristics and immune biomarkers were assessed using logistic regression models.

resultCompared to women of a normal BMI, obese women (>30 kg/m

conclusionsSeveral host characteristics were associated with circulating levels of immune biomarkers, including markers of inflammation. Further understanding of associations between immune marker profiles with human disease are warranted.

Indexed as

BiomarkersB-LymphocytesBody Mass IndexCross-Sectional StudiesCytokinesExerciseFemaleHumansInflammationLogistic ModelsMacrophage ActivationMacrophagesOdds RatioProspective StudiesT-LymphocytesBiomarkersCytokinesBloodCirculating markersCross-sectionalDiabetesEpidemiologyHumanInflammationObesityPhysical activityStatins

Identifiers

PMID34666235
PMCPMC8680201
OpenAlexW3205414221

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.