Evidence map›Paper›PMID 34667117›Full record

ArticleGenome research2021

Positive selection in noncoding genomic regions of vocal learning birds is associated with genes implicated in vocal learning and speech functions in humans.

James A Cahill, Joel Armstrong, Alden Deran, Carolyn J Khoury, Benedict Paten, David Haussler, Erich D Jarvis

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

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  4. Assessing the Role of Vocal Plasticity in Sociospatial Coordination.Animals : an open access journal from MDPI · 2026
    Review
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  14. A genomic basis of vocal rhythm in birds.Nature communications · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

James A CahillLaboratory of Neurogenetics of Language, The Rockefeller University, New York, New York 10065, USA.ORCID 0000-0002-7145-0215
Joel ArmstrongJack Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Alden DeranJack Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Carolyn J KhouryLaboratory of Neurogenetics of Language, The Rockefeller University, New York, New York 10065, USA.
Benedict PatenJack Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
David HausslerJack Baskin School of Engineering, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Erich D JarvisLaboratory of Neurogenetics of Language, The Rockefeller University, New York, New York 10065, USA.
University of California, Santa Cruz · USRockefeller University · USHoward Hughes Medical Institute · US

Funding

Training SubprojectU54HG007990 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, PATTERSON, DAVID · 2014 to 2018
$14.8M
Unbiased analysis of genomic correlates of gene expression in health and diseaseU01HL137183 · NHLBI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H · 2017 to 2019
$1.8M
Howard Hughes Medical InstituteNHGRI NIH HHS U54 HG007990NHLBI NIH HHS U01 HL137183
6 · The paper itself

Abstract

Vocal learning, the ability to imitate sounds from conspecifics and the environment, is a key component of human spoken language and learned song in three independently evolved avian groups-oscine songbirds, parrots, and hummingbirds. Humans and each of these three bird clades exhibit specialized behavioral, neuroanatomical, and brain gene expression convergence related to vocal learning, speech, and song. To understand the evolutionary basis of vocal learning gene specializations and convergence, we searched for and identified accelerated genomic regions (ARs), a marker of positive selection, specific to vocal learning birds. We found avian vocal learner-specific ARs, and they were enriched in noncoding regions near genes with known speech functions or brain gene expression specializations in humans and vocal learning birds, including

Indexed as

SongbirdsSpeechAnimalsBrainGenomicsHumansLearningRepressor ProteinsTumor Suppressor ProteinsVocalization, AnimalBCL11B protein, humanRepressor ProteinsTumor Suppressor Proteins

Identifiers

PMID34667117
PMCPMC8559704
OpenAlexW3207241995

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.