Evidence map›Paper›PMID 34667213›Full record

ArticleScientific reports2021

Mouse Dspp frameshift model of human dentinogenesis imperfecta.

Tian Liang, Yuanyuan Hu, Hong Zhang, Qian Xu, Charles E Smith, Chuhua Zhang, Jung-Wook Kim, Shih-Kai Wang, Thomas L Saunders, Yongbo Lu and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. JBMR plus · 2026
    Article
  5. Functions of secretory calcium-binding phosphoproteins in dental mineralization.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  6. Article
  7. Journal of dental research · 2024
    Article
  8. Article
  9. Article
  10. Dentin defects caused by a DsppScientific reports · 2023
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Tian LiangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
Yuanyuan HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
Hong ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
Qian XuDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, 3302 Gaston Ave., Dallas, TX, 75246, USA.
Charles E SmithDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
Chuhua ZhangDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
Jung-Wook KimDepartment of Molecular Genetics, School of Dentistry & Dental Research Institute, Seoul National University, Seoul, Korea.
Shih-Kai WangDepartment of Dentistry, National Taiwan University School of Dentistry, No.1, Changde St., Jhongjheng District, Taipei City 100, Taiwan.
Thomas L SaundersDepartment of Internal Medicine, University of Michigan Medical School, 1150 West Medical Center Drive, MSRBII Room 2570, Ann Arbor, MI, 41809, USA.
Yongbo LuDepartment of Biomedical Sciences and Center for Craniofacial Research and Diagnosis, Texas A&M University College of Dentistry, 3302 Gaston Ave., Dallas, TX, 75246, USA.
Jan C-C HuDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA.
James P SimmerDepartment of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48108, USA. jsimmer@umich.edu.
University of Michigan–Ann Arbor · USTexas A&M University · USMcGill University · CANational Taiwan University · TWRegional West Medical Center · USSeoul National University · KR

Funding

DSPP Function, Pathophysiology, and Genetic DiagnosisR01DE027675 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SIMMER, JAMES P · 2018 to 2022
$2.4M
Dentin Sialophosphoprotein (DSPP) and Unfolded Protein Response (UPR) in Dentinogenesis Imperfecta (DGI) and Odontoblast FunctionR01DE027345 · NIDCR · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI LU, YONGBO, QIN, CHUNLIN · 2018 to 2022
$1.8M
NIDCR NIH HHS DE027345NIDCR NIH HHS DE027675NIDCR NIH HHS R01 DE027345NIDCR NIH HHS R01 DE027675
6 · The paper itself

Abstract

Non-syndromic inherited defects of tooth dentin are caused by two classes of dominant negative/gain-of-function mutations in dentin sialophosphoprotein (DSPP): 5' mutations affecting an N-terminal targeting sequence and 3' mutations that shift translation into the - 1 reading frame. DSPP defects cause an overlapping spectrum of phenotypes classified as dentin dysplasia type II and dentinogenesis imperfecta types II and III. Using CRISPR/Cas9, we generated a Dspp

Indexed as

AnimalsDental EnamelDentinDentinogenesis ImperfectaDentin SialophosphoproteinDisease Models, AnimalExtracellular Matrix ProteinsFemaleFrameshift MutationHumansMaleMiceMice, TransgenicPhenotypePhosphoproteinsSialoglycoproteinsDentin SialophosphoproteinExtracellular Matrix ProteinsPhosphoproteinsSialoglycoproteins

Identifiers

PMID34667213
PMCPMC8526674
OpenAlexW3207924913

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.