Evidence map›Paper›PMID 34669010›Full record

ArticleArchives of toxicology2022

Physiologically based kinetic modelling predicts the in vivo relative potency of riddelliine N-oxide compared to riddelliine in rat to be dose dependent.

Frances Widjaja, Sebastiaan Wesseling, Ivonne M C M Rietjens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Frances WidjajaDivision of Toxicology, Wageningen University, Stippeneng 4, PO Box 8000, 6708 WE, Wageningen, The Netherlands. frances1.widjaja@wur.nl.ORCID 0000-0003-3035-7986
Sebastiaan WesselingDivision of Toxicology, Wageningen University, Stippeneng 4, PO Box 8000, 6708 WE, Wageningen, The Netherlands.
Ivonne M C M RietjensDivision of Toxicology, Wageningen University, Stippeneng 4, PO Box 8000, 6708 WE, Wageningen, The Netherlands.
Wageningen University & Research · NL

Funding

Wageningen University 61.390.40.890
6 · The paper itself

Abstract

Pyrrolizidine alkaloids (PAs) are toxic plant constituents occurring often in their N-oxide form. This raises the question on the relative potency (REP) values of PA-N-oxides compared to the corresponding parent PAs. The present study aims to quantify the in vivo REP value of riddelliine N-oxide compared to riddelliine using physiologically based kinetic (PBK) modelling, taking into account that the toxicity of riddelliine N-oxide depends on its conversion to riddelliine by intestinal microbiota and in the liver. The models predicted a lower C

Indexed as

Pyrrolizidine AlkaloidsAnimalsKineticsLiverRatsPyrrolizidine Alkaloidsriddelliineriddelliine N-oxideIntestinal microbiotaPhysiologically based kinetic (PBK) modelRelative potency (REP) valueRiddelliineRiddelliine N-oxide

Identifiers

PMID34669010
PMCPMC8748370
OpenAlexW3207143656

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.