Evidence map›Paper›PMID 34669461›Full record

ArticleJournal of virology2022

High-Throughput Screening Identifies Inhibitors for Parvovirus B19 Infection of Human Erythroid Progenitors.

Kang Ning, Anuradha Roy, Fang Cheng, Peng Xu, Steve Kleiboeker, Carlos R Escalante, Jingxin Wang, Jianming Qiu

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Kang NingDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Anuradha RoyHigh Throughput Screening Laboratory, Shankel Structural Biology Center, University of Kansasgrid.412016.0grid.266515.3grid.412016.0grid.266515.3, Lawrence, Kansas, USA.
Fang ChengDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Peng XuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Steve KleiboekerDepartment of Research and Development, ViraCor Eurofins Laboratories, Lee's Summit, Missouri, USA.
Carlos R EscalanteDepartment of Physiology and Biophysics, VCU School of Medicine, Richmond, Virginia, USA.
Jingxin WangDepartment of Medicinal Chemistry, University of Kansasgrid.412016.0grid.266515.3grid.412016.0grid.266515.3, Lawrence, Kansas, USA.
Jianming QiuDepartment of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0001-9850-1695
University of Kansas Medical Center · USChildren's Hospital of Richmond at VCU · USEurofins (United States) · USUniversity of Kansas · US

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OROZCO, ROBIN C. · 2016 to 2025
$23.9M
Structural and Mechanistic Insights into AAV Rep Mediated Site-Specific Integration and PackagingR01GM124204 · NIGMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Carlos R Escalante · 2017 to 2026
$4.2M
Viral and Host Determinants of Parvovirus ReplicationR01AI150877 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2020 to 2024
$2.4M
Parvovirus B19 NS1 nickase-based high-throughput screening and structure study of the nickaseR21AI144564 · NIAID · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QIU, JIANMING · 2019 to 2020
$421k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI144564NIAID NIH HHS R01 AI150877NIAID NIH HHS R21 AI144564NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R01 GM124204
6 · The paper itself

Abstract

Parvovirus B19 (B19V) infection can cause hematological disorders and fetal hydrops during pregnancy. Currently, no antivirals or vaccines are available for the treatment or prevention of B19V infection. To identify novel small-molecule antivirals against B19V replication, we developed a high-throughput screening (HTS) assay, which is based on an

Indexed as

Antiviral AgentsCell SurvivalDNA ReplicationDNA, ViralErythroid Precursor CellsFluorescent DyesHigh-Throughput Screening AssaysHumansParvovirus B19, HumanRecombinant ProteinsReplication OriginSmall Molecule LibrariesViral Nonstructural ProteinsVirus ReplicationAntiviral AgentsDNA, ViralFluorescent DyesNS1 protein, parvovirusRecombinant ProteinsSmall Molecule LibrariesViral Nonstructural Proteinsantiviral agentsantiviralsB19VDNA replicationerythroid progenitorshematological disordershuman erythroid progenitorsparvovirus

Identifiers

PMID34669461
PMCPMC8791288
OpenAlexW3207445277

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.