ArticleAmerican journal of physiology. Cell physiology2021
Endothelial upregulation of mechanosensitive channel Piezo1 in pulmonary hypertension.
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In one paragraph
Article in American journal of physiology. Cell physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
80 citing papers in PubMed, 100 citations in OpenAlex.
- Mechanosensitive Stanniocalcin-1 Suppresses Smooth Muscle Cell Proliferation and Attenuates Experimental Pulmonary Hypertension.Circulation research · 2026Article
- Piezo channels in physical field therapy: From mechanotransduction mechanisms to bioelectromagnetic modulation and biomedical applications.Mechanobiology in medicine · 2026Review
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The Role of Piezo Ion Channels in Pulmonary Hypertension.Pulmonary circulation · 2026Review
- Functional Role of Piezo1 in Regulating Whole-Lung Vascular Reactivity.Pulmonary circulation · 2026Article
- Mechanical activation of Piezo1 promotes osteoclastogenesis in orthodontic tooth movement.BMC oral health · 2026Article
- Pulmonary Vascular Signaling in Pulmonary Hypertension: Potential Role of Endothelial CaArteriosclerosis, thrombosis, and vascular biology · 2026Review
- Mechanical compression causes lung hypoplasia in congenital diaphragmatic hernia with GATA4 genetic variants.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Advances in the pathogenesis and clinical management of pulmonary hypertension.Medical review (2021) · 2026Review
- Piezo1 specific deletion in endothelial cell protects the progression of pulmonary fibrosis in mice.Cell communication and signaling : CCS · 2026Article
- The Emerging Role of Mechanobiology in Connecting Metabolic and Cardiovascular Diseases: From Fundamentals to Future Therapies.Biomedicines · 2026Review
- The Vascular-Immune Cells Crosstalk and Microenvironment in Pulmonary Hypertension.Comprehensive physiology · 2026Review
- Mechanoresponsive ion channels Piezo1 and TRPV4 stimulate ADAM10 and ADAM17 with differential impact on endothelial migration and proliferation.Cell communication and signaling : CCS · 2026Article
- Increased vein wall thickness in Behçet's disease: from intravascular mechanical stress to vascular remodelling and venous thrombosis.Rheumatology international · 2026Review
- The Mechanosensitive Ion Channel Piezo1 Promotes Obliterative Bronchiolitis through YAP-dependent Epithelial-to-mesenchymal Transition.Current molecular medicine · 2026Article
- Piezo1 in respiratory diseases: mechanotransduction, cell-specific functions, and translational implications.Frontiers in physiology · 2026Review
- A second-hit conceptual framework for pulmonary arterial hypertension in adult congenital heart disease: genetics, hemodynamics, and treat-and-repair.Frontiers in cardiovascular medicine · 2026Review
- From plasma membrane to lysosomes: expanding roles of TMEM63/OSCA channels in mechanosensation and intracellular signaling.Frontiers in pharmacology · 2026Review
- Article
- Patient-specific hemodynamic simulation for left ventricular assist device via non-invasive monitoring based on lumped parameter model and hierarchical neural network.Frontiers in physiology · 2026Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 2 institutions in 2 countries.
Ziyi WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Jiyuan ChenSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Aleksandra BabichevaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Pritesh P JainSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Marisela RodriguezSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Ramon J AyonDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Keeley S RavelletteDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Linda WuDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Francesca BalistrieriSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Haiyang TangDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Xiaomin WuDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Tengteng ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Stephen M BlackDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Ankit A DesaiDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.
Joe G N GarciaDepartments of Medicine and Physiology, The University of Arizona College of Medicine, Tucson, Arizona.ORCID 0000-0002-6934-0420
Xin SunDepartment of Pediatrics, University of California, San Diego, La Jolla, California.ORCID 0000-0001-8387-4966
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Daniela Valdez-JassoDepartment of Bioengineering, University of California, San Diego, La Jolla, California.ORCID 0000-0001-7121-2121
Patricia A ThistlethwaiteDepartment of Surgery, University of California, San Diego, La Jolla, California.
Ayako MakinoDivision of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California.
Jian WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.
Jason X-J YuanSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, La Jolla, California.ORCID 0000-0002-0685-4862
University of Arizona · USUniversity of California San Diego · US
Funding
Training In Cardiovascular Physiology & PharmacologyT32HL007444 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ju Chen, Robert Scott Ross · 1985 to 2026
$11.1MIon Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6MUCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3MMolecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1MPathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4MReplacement of Small Animal Echocardiographic InstrumentationS10OD010417 · OD · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI ROSS, ROBERT SCOTT · 2012 to 2012
$371kHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL146864NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL136603NHLBI NIH HHS R25 HL145817NHLBI NIH HHS R35 HL135807NHLBI NIH HHS T32 HL007444NIH HHS S10 OD010417
Abstract
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca
Indexed as
AdultAgedAnimalsCells, CulturedEndothelial CellsFemaleHumansHypertension, PulmonaryIndolesIon ChannelsMaleMechanotransduction, CellularMiceMice, Inbred C57BLMiddle AgedPulmonary ArteryIndolesIon ChannelsPIEZO1 protein, humanPyrrolesSemaxinibcalcium signalingmechanosensationmembrane stretchnovel channelspulmonary artery
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.