ArticleThe Journal of allergy and clinical immunology2022
Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children.
Article in The Journal of allergy and clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Associations between genetic ancestry and allergic outcomes at 10 years among Black children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026Article
- Factors associated with acute unscheduled care visits for asthma in the all of US dataset.The American journal of emergency medicine · 2025Article
- Genome-wide cross-trait analysis of heterogeneous outcomes in early life atopic dermatitis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Clustering analysis of circulating plasma-biomarkers in atopic dermatitis reveals a distinct-inflammatory cardiac risk profile in African American patients.Research square · 2025Article
- Socioeconomic deprivation performs equally to race in the Pediatric Asthma Risk Score.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Skin Staphylococcus aureus detection and relationship to atopic dermatitis outcomes using culture and metagenomic sequencing.Scientific reports · 2025Article
- A prospective clinical study of allergy progression in identical and fraternal twin pairs of children.Translational pediatrics · 2025Article
- Race-Specific and Race-Neutral Equations for Lung Function and Asthma Diagnosis in Black Children.JAMA network open · 2025Article
- Moving beyond biology: the critical role of social and structural determinants in atopic dermatitis.International journal of dermatology · 2025Review
- Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis.Dermatology research and practice · 2025Article
- The Relationship Between Asthma and Food Allergies in Children.Children (Basel, Switzerland) · 2024Review
- Reducing disparities in the care of atopic dermatitis.Archives of dermatological research · 2024Review
- Analyzing Racial Disparities in Pediatric Atopic Comorbidity Emergency Department Visitation Using Electronic Health Records.The journal of allergy and clinical immunology. In practice · 2024Article
- Atopic dermatitis phenotype affects expression of atopic diseases despite similar mononuclear cell cytokine response.The Journal of allergy and clinical immunology · 2024Article
- Early life risk factors of Atopic March in a high-risk, minority, urban, low-income, prospective birth cohort.Allergy · 2024Article
- Genetic and Immunological Pathogenesis of Atopic Dermatitis.The Journal of investigative dermatology · 2024Review
- Filaggrin loss-of-function variants are associated with atopic dermatitis phenotypes in a diverse, early-life prospective cohort.JCI insight · 2024Article
- Racial differences in length of stay and readmission for asthma in the all of us research program.Journal of translational medicine · 2024Article
- Temporal relationships between Staphylococcus aureus colonization, filaggrin expression, and pediatric atopic dermatitis.Allergy · 2024Article
- Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts.The British journal of dermatology · 2023Article
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe atopic march has been studied mostly in White populations, biasing our current paradigms.
objectiveWe sought to define the atopic march in Black and White children and explore mechanisms for racial differences.
methodsUtilizing the Mechanisms of Progression of Atopic Dermatitis to Asthma in Children (MPAACH) cohort (n = 601), we assessed longitudinal sensitization, food allergy (FA), allergic rhinitis, risk of asthma development (through the Pediatric Asthma Risk Score), Scoring for Atopic Dermatitis (SCORAD), transepidermal water loss, skin filaggrin (FLG) expression, exposures, and genetic heritability to define AD progression endotypes in Black and White children.
resultsWhite MPAACH children were more likely to be sensitized to aero and food allergens (P = .0001) and over 3 times more likely to develop FA and/or allergic rhinitis (AR) without asthma risk (P < .0001). In contrast, Black children were over 6 times more likely to proceed to high asthma risk without FA, sensitization, or AR (P < .0001). White children had higher lesional and nonlesional transepidermal water loss (both P < .001) as well as decreased nonlesional keratinocyte FLG expression (P = .02). Black children had increased genetic heritability for asthma risk and higher rates of exposures to secondhand smoke and traffic-related air pollution.
conclusionsBlack and White children with AD have distinct allergic trajectories defined by different longitudinal endotypes. Black children exhibit higher asthma risk despite a more intact skin barrier and less sensitization, FA, and AR. White children have less asthma risk, despite a more dysfunctional skin barrier, and more FA, AR, and sensitization. The observed racial differences are likely due in part to increased genetic heritability for asthma risk and harmful environmental exposures in Black children. Collectively, our findings provide a new paradigm for an atopic march that is inclusive of Black children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.