Evidence map›Paper›PMID 34675729›Full record

ReviewNature and science of sleep2021

Acupuncture: A Promising Approach for Comorbid Depression and Insomnia in Perimenopause.

Fei-Yi Zhao, Qiang-Qiang Fu, Sarah J Spencer, Gerard A Kennedy, Russell Conduit, Wen-Jing Zhang, Zhen Zheng

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature and science of sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 10 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 10 syntheses or guidelines pooled it, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Fei-Yi ZhaoSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.ORCID 0000-0001-9009-8870
Qiang-Qiang FuYangpu Hospital, School of Medicine, Tongji University, Shanghai, 200090, People's Republic of China.ORCID 0000-0002-2369-1508
Sarah J SpencerSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.ORCID 0000-0001-8832-4824
Gerard A KennedySchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.ORCID 0000-0002-4419-050X
Russell ConduitSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.ORCID 0000-0001-9356-6844
Wen-Jing ZhangShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200071, People's Republic of China.ORCID 0000-0002-3716-6800
Zhen ZhengSchool of Health and Biomedical Sciences, RMIT University, Bundoora, Victoria, 3083, Australia.ORCID 0000-0001-6777-1166
RMIT University · AUFederation University · AUSanda University · CNShanghai University of Traditional Chinese Medicine · CNYangpu Hospital of Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comorbid depression and insomnia are ubiquitous mental complaints among women going through the perimenopausal stage of life and can result in major decline in quality of life. Antidepressive agents combined with/without hypnotics, and/or hormone therapy are currently the most common treatment for perimenopausal depression (PMD) and insomnia (PMI). Balancing the benefits of these pharmacotherapies against the risk of adverse events (AEs) is a difficult task for both clinicians and women. There has been a growing body of research regarding the utilization of acupuncture for treatment of PMD or PMI, whereas no studies of acupuncture for comorbid PMD and PMI have appeared. In this review, we summarize the clinical and preclinical evidence of acupuncture as a treatment for PMD or PMI, and then discuss the potential mechanisms involved and the role of acupuncture in helping women during this transition. Most clinical trials indicate that acupuncture ameliorates not only PMD/PMI but also climacteric symptoms with minimal AEs. It also regulates serum hormone levels. The reliability of trials is however limited due to methodological flaws in most studies. Rodent studies suggest that acupuncture prolongs total sleep time and reduces depression-like behavior in PMI and PMD models, respectively. These effects are possibly mediated through multiple mechanisms of action, including modulating sex hormones, neurotransmitters, hypothalamic-pituitary-adrenal axis/hypothalamic-pituitary-ovary axis, oxidative stress, signaling pathways, and other cellular events. In conclusion, acupuncture is a promising therapeutic strategy for comorbid depression and insomnia during perimenopause. Neuroendocrine modulation is likely to play a major role in mediating those effects. High-quality trials are required to further validate acupuncture's effectiveness.

Indexed as

acupuncturecomorbiddepressioninsomniamechanismsperimenopause

Identifiers

PMID34675729
PMCPMC8520448
OpenAlexW3206135031

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.