ArticleFrontiers in endocrinology2021
The Roles of Genetic and Early-Life Environmental Factors in the Association Between Overweight or Obesity and Hypertension: A Population-Based Twin Study.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Female-specific hypertension risk factors across the lifecourse: a co-twin control analysis using the California Twin Program.American journal of epidemiology · 2026Article
- Association between external eating and dietary patterns among middle school students in Chongqing, China.Frontiers in nutrition · 2025Article
- Prehypertension and its associated factors among government employees in Tilottama Municipality of Rupandehi District, Nepal.PloS one · 2025Article
- Parents of children and adolescents knowledge, attitude, and practice toward metabolically healthy obesity: a cross-sectional survey.Frontiers in public health · 2025Article
- A Rare Case of Postoperative Encephalopathy in Twin.Cureus · 2023Article
- The associations of obesity phenotypes with the risk of hypertension and its transitions among middle-aged and older Chinese adults.Epidemiology and health · 2023Article
- Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation.Current nutrition reports · 2022Review
- Hypertension Related to Obesity: Pathogenesis, Characteristics and Factors for Control.International journal of molecular sciences · 2022Review
- Article
- Impact of maternal gestational weight gain in twin pregnancies on early childhood obesity risk: A longitudinal birth cohort study.Frontiers in pediatrics · 2022Article
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Authors and funding
23 authors at 12 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims/Hypothesis: We aimed to explore whether and to what extent overweight or obesity could increase the risk of hypertension, and further to estimate the roles of genetic and early-life familial environmental factors in their association. Methods: This prospective twin study was based on the Chinese National Twin Registry (CNTR), which collected information from self-report questionnaires. We conducted unmatched case-control analysis to examine the association between overweight or obesity and hypertension. And further to explore whether genetics and familiar environments shared within a twin pair, accounted for their association Results: Overall, we included a total of 30,617 twin individuals, of which 7533 (24.6%) twin participants were overweight or obesity and 757 (2.5%) developed hypertension during a median follow-up time of 4.4 years. In the GEE model, overweight or obesity was associated with a 94% increased risk of hypertension (OR=1.94, 95% confidence interval (CI): 1.64~2.30). In the conditional logistic regression, the multi-adjusted OR was 1.80 (95% CI: 1.18~2.74). The difference in OR between unmatched and matched analyses was significant ( Conclusions/Interpretation: Genetics and early-life environments shared by participants within a twin pair appear to account for the association between overweight or obesity and hypertension risk.
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