Evidence map›Paper›PMID 34678128›Full record

Trial reportAnnals of the American Thoracic Society2022

A Phase-2 Exploratory Randomized Controlled Trial of INOpulse in Patients with Fibrotic Interstitial Lung Disease Requiring Oxygen.

Christopher S King, Kevin R Flaherty, Marilyn K Glassberg, Lisa Lancaster, Ganesh Raghu, Jeffrey J Swigris, Rahul G Argula, Rosemarie A Dudenhofer, Neil A Ettinger, Jeremy Feldman and 5 more

Abstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Annals of the American Thoracic Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Physical activity measurements in individuals with interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023
    Pooled it
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  19. The nitric oxide-soluble guanylate cyclase-cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 1 country.

Christopher S KingAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia.
Kevin R FlahertyUniversity of Michigan, Ann Arbor, Michigan.
Marilyn K GlassbergUniversity of Arizona, Tucson, Arizona.
Lisa LancasterVanderbilt University Medical Center, Nashville, Tennessee.
Ganesh RaghuUniversity of Washington, Seattle, Washington.
Jeffrey J SwigrisNational Jewish Medical Center, Denver, Colorado.
Rahul G ArgulaMedical University of South Carolina, Charleston, South Carolina.
Rosemarie A DudenhoferVanderbilt University Medical Center, Nashville, Tennessee.
Neil A EttingerSt. Luke's Hospital, Chesterfield, Missouri.
Jeremy FeldmanArizona Pulmonary Specialists, Phoenix, Arizona.
Shilpa JohriPulmonary Associates of Richmond, Richmond, Virginia; and.
Peter FernandesBellerophon Therapeutics, Warren, New Jersey.
Ed ParsleyBellerophon Therapeutics, Warren, New Jersey.
Parag S ShahBellerophon Therapeutics, Warren, New Jersey.
Steven D NathanAdvanced Lung Disease and Transplant Program, Inova Fairfax Hospital, Falls Church, Virginia.
Bellerophon Therapeutics (United States) · USInova Fairfax Hospital · USVanderbilt University Medical Center · USArizona Pain Specialists · USMedical University of South Carolina · USNational Jewish Health · USPulmonary Associates · USSt. Luke's Hospital · USUniversity of Arizona · USUniversity of Michigan · USUniversity of Washington · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Lung Diseases, InterstitialOxygenActivities of Daily LivingDyspneaHumansQuality of LifeTreatment OutcomeOxygeninterstitial lung diseasenitric oxidepulmonary fibrosispulmonary hypertension

Identifiers

PMID34678128
OpenAlexW3207160890

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.