Evidence map›Paper›PMID 34679698›Full record

ReviewAntioxidants (Basel, Switzerland)2021

Role of Food Antioxidants in Modulating Gut Microbial Communities: Novel Understandings in Intestinal Oxidative Stress Damage and Their Impact on Host Health.

Muhammad Shahid Riaz Rajoka, Rohit Thirumdas, Hafiza Mahreen Mehwish, Muhammad Umair, Mohsin Khurshid, Hafiz Fakhar Hayat, Yuthana Phimolsiripol, Noelia Pallarés, Francisco J Martí-Quijal, Francisco J Barba

Open access · goldAbstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  5. Review
  6. Marine Collagen Peptide Fraction fromFoods (Basel, Switzerland) · 2026
    Article
  7. Dietary Supplementation withAnimals : an open access journal from MDPI · 2026
    Article
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  10. Article
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  17. Frontiers in microbiology · 2026
    Article
  18. Review
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  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 6 countries.

Muhammad Shahid Riaz RajokaHealth Science Center, School of Pharmaceutical Science, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0003-0137-4584
Rohit ThirumdasCollege of Food Science and Technology, PJTSAU, Hyderabad 500030, India.
Hafiza Mahreen MehwishHealth Science Center, School of Pharmaceutical Science, Shenzhen University, Shenzhen 518060, China.
Muhammad UmairCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.ORCID 0000-0002-2035-686X
Mohsin KhurshidDepartment of Microbiology, Government College University, Faisalabad Government College University, Faisalabad 38000, Pakistan.ORCID 0000-0002-3196-2857
Hafiz Fakhar HayatDepartment of Microbiology, Government College University, Faisalabad Government College University, Faisalabad 38000, Pakistan.
Yuthana PhimolsiripolFaculty of Agro-Industry, Chiang Mai University, Chiang Mai 50100, Thailand.ORCID 0000-0003-3521-1599
Noelia PallarésDepartment of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, 46100 València, Spain.ORCID 0000-0001-8018-3959
Francisco J Martí-QuijalDepartment of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, 46100 València, Spain.ORCID 0000-0001-9034-5325
Francisco J BarbaDepartment of Preventive Medicine and Public Health, Food Science, Toxicology and Forensic Medicine, Faculty of Pharmacy, Universitat de València, Avda. Vicent Andrés Estellés, 46100 València, Spain.ORCID 0000-0002-5630-3989
Universitat de València · ESGovernment College University, Faisalabad · PKShenzhen University · CNChiang Mai University · THProfessor Jayashankar Telangana State Agricultural University · INShenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dietary components have an important role on the structure and function of host gut microbial communities. Even though, various dietary components, such as carbohydrates, fats, proteins, fibers, and vitamins, have been studied in depth for their effect on gut microbiomes, little attention has been paid regarding the impact of several food antioxidants on the gut microbiome. The long-term exposure to reactive oxygen species (ROS) can cause microbial dysbiosis which leads to numerous intestinal diseases such as microbiota dysbiosis, intestinal injury, colorectal cancers, enteric infections, and inflammatory bowel diseases. Recently, it has been shown that the food derived antioxidant compounds might protect the host from intestinal oxidative stress via modulating the composition of beneficial microbial species in the gut. The present review summarizes the impact of food antioxidants including antioxidant vitamins, dietary polyphenols, carotenoids, and bioactive peptides on the structure as well as function of host gut microbial communities. Several in vitro, animal model, and clinical studies indicates that food antioxidants might modify the host gut microbial communities and their health status. However, still further clarification is needed as to whether changes in certain microbial species caused by food additives may lead to changes in metabolism and immune function.

Indexed as

antioxidantsbioactive peptidesfood additivegut microbiotapolyphenolvitamins

Identifiers

PMID34679698
PMCPMC8533511
OpenAlexW3202973980

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.