Evidence map›Paper›PMID 34680288›Full record

ArticleCancers2021

Jessica Merkle, Markus Breunig, Maximilian Schmid, Chantal Allgöwer, Jana Krüger, Michael K Melzer, Susanne Bens, Reiner Siebert, Lukas Perkhofer, Ninel Azoitei and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Organoid technology in cancer research.Molecular biomedicine · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Decoding cancer etiology with cellular reprogramming.Current opinion in genetics & development · 2025
    Review
  6. Review
  7. Clinical significance and prospective mechanism of increased CDKN2A expression in small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Jessica MerkleDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Markus BreunigDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0002-2817-1974
Maximilian SchmidDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Chantal AllgöwerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Jana KrügerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Michael K MelzerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0002-7902-590X
Susanne BensDepartment of Human Genetics, Ulm University & Ulm University Hospital, 89081 Ulm, Germany.
Reiner SiebertDepartment of Human Genetics, Ulm University & Ulm University Hospital, 89081 Ulm, Germany.
Lukas PerkhoferDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0003-0484-0974
Ninel AzoiteiDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Thomas SeufferleinDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Sandra HellerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0002-8704-2646
Matthias MeierHelmholtz Pioneer Campus, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
Martin MüllerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.
Alexander KlegerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0003-0592-5232
Meike HohwielerDepartment of Internal Medicine I, Ulm University Hospital, 89081 Ulm, Germany.ORCID 0000-0002-0640-0764
University Hospital Ulm · DEHelmholtz Zentrum München · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patient-derived induced pluripotent stem cells (iPSCs) provide a unique platform to study hereditary disorders and predisposition syndromes by resembling germline mutations of affected individuals and by their potential to differentiate into nearly every cell type of the human body. We employed plucked human hair from two siblings with a family history of cancer carrying a pathogenic

Indexed as

CDKN2Afamilial pancreatic cancerinduced pluripotent stem cellspancreatic organoids

Identifiers

PMID34680288
PMCPMC8533699
OpenAlexW3206558236

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.