Evidence map›Paper›PMID 34680294›Full record

ArticleCancers2021

Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.

Wai C Chong, W Samantha N Jayasekara, Vijesh G Vaghjiani, Sarah Parackal, Claire Sun, Dean Popovski, Elizabeth M Algar, Ron Firestein, Paul J Wood, Sara Khan and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Small-Molecule Drugs in Pediatric Neuro-Oncology.Current oncology (Toronto, Ont.) · 2025
    Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Wai C ChongCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
W Samantha N JayasekaraCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Vijesh G VaghjianiCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Sarah ParackalCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0003-4128-4073
Claire SunCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0002-2124-3074
Dean PopovskiCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Elizabeth M AlgarCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Ron FiresteinCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Paul J WoodChildren's Cancer Centre, Monash Children's Hospital, Monash Health, Clayton, VIC 3168, Australia.
Sara KhanCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Annie HuangArthur and Sonia Labatt Brain Tumor Research Centre, Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON M5G 1X8, Canada.
David M AshleyThe Preston Robert Tisch Brain Tumor Centre at Duke, Duke University Medical Centre, Durham, NC 27710, USA.
Peter DownieChildren's Cancer Centre, Monash Children's Hospital, Monash Health, Clayton, VIC 3168, Australia.
Jason E CainCentre for Cancer Research, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0003-3987-5894
Hudson Institute of Medical Research · AUMonash Children’s Hospital · AUDuke University · USHospital for Sick Children · CAUniversity of Toronto · CA

Funding

Bailey's Day n/aVictorian Cancer Agency MCRF17014
6 · The paper itself

Abstract

Atypical teratoid rhabdoid tumour (ATRT) is a rare but highly aggressive undifferentiated solid tumour arising in the central nervous system and predominantly affecting infants and young children. ATRT is exclusively characterized by the inactivation of

Indexed as

atypical teratoid rhabdoid tumourdifferentiationHDACipanobinostat

Identifiers

PMID34680294
PMCPMC8534272
OpenAlexW3205657594

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.