Evidence map›Paper›PMID 34681663›Full record

ArticleInternational journal of molecular sciences2021

Proteomic Landscape of Extracellular Vesicles for Diffuse Large B-Cell Lymphoma Subtyping.

Ana Sofia Carvalho, Henrique Baeta, Andreia F A Henriques, Mostafa Ejtehadifar, Erin M Tranfield, Ana Laura Sousa, Ana Farinho, Bruno Costa Silva, José Cabeçadas, Paula Gameiro and 3 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Review
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  12. Article
  13. Article
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  15. Article
  16. Article
  17. IgGCells · 2022
    Article
  18. Extracellular Vesicles in Haematological Disorders: A Friend or a Foe?International journal of molecular sciences · 2022
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ana Sofia CarvalhoComputational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0003-0657-1907
Henrique BaetaComputational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0001-8481-9416
Andreia F A HenriquesComputational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0001-7763-873X
Mostafa EjtehadifarComputational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0002-6508-8707
Erin M TranfieldElectron Microscopy Facility, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
Ana Laura SousaElectron Microscopy Facility, Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.ORCID 0000-0001-6067-8794
Ana FarinhoiNOVA4Health-Advancing Precision Medicine, CEDOC-Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.
Bruno Costa SilvaSystems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.ORCID 0000-0002-5932-6211
José CabeçadasPathology Department, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisbon, Portugal.ORCID 0000-0001-6232-1596
Paula GameiroHaematology Unit, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisbon, Portugal.ORCID 0000-0002-3761-7050
Maria Gomes da SilvaHaematology Unit, Instituto Português de Oncologia de Lisboa Francisco Gentil, 1099-023 Lisbon, Portugal.ORCID 0000-0002-6993-2450
Hans Christian BeckCentre for Clinical Proteomics, Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, DK-5000 Odense, Denmark.ORCID 0000-0002-7763-3637
Rune MatthiesenComputational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-056 Lisbon, Portugal.ORCID 0000-0002-6353-2616
Universidade Nova de Lisboa · PTInstituto Gulbenkian de Ciência · PTChampalimaud Foundation · PTOdense University Hospital · DK

Funding

Fundação para a Ciência e Tecnologia PTDC/BTM-TEC/30087/2017
6 · The paper itself

Abstract

The role of extracellular vesicles (EVs) proteome in diffuse large B-cell lymphoma (DLBCL) pathology, subclassification, and patient screening is unexplored. We analyzed by state-of-the-art mass spectrometry the whole cell and secreted extracellular vesicles (EVs) proteomes of different molecular subtypes of DLBCL, germinal center B cell (GCB subtype), and activated B cell (ABC subtype). After quality control assessment, we compared whole-cell and secreted EVs proteomes of the two cell-of-origin (COO) categories, GCB and ABC subtypes, resulting in 288/1115 significantly differential expressed proteins from the whole-cell proteome and 228/608 proteins from EVs (adjust

Indexed as

B-LymphocytesCell Line, TumorExtracellular VesiclesGerminal CenterHumansLymphoma, Large B-Cell, DiffuseMass SpectrometryProteomeProteomicsProteomediffuse large B-cell lymphomaDLBCLexosomesextracellular vesiclesmass spectrometryproteomics

Identifiers

PMID34681663
PMCPMC8536203
OpenAlexW3207118462

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.