Evidence map›Paper›PMID 34681805›Full record

ArticleInternational journal of molecular sciences2021

Trimethylamine

Laura Díez-Ricote, Paloma Ruiz-Valderrey, Víctor Micó, Ruth Blanco-Rojo, João Tomé-Carneiro, Alberto Dávalos, José M Ordovás, Lidia Daimiel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Gut Microbiota-Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  9. Review
  10. Article
  11. Evidence for a TMAO-HULC-miRNA regulatory axis in colorectal cancer cells.International journal of molecular and cellular medicine · 2025
    Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story.International journal of molecular sciences · 2023
    Review
  18. Article
  19. Tackling Atherosclerosis via Selected Nutrition.International journal of molecular sciences · 2022
    Review
  20. The Underlying Pathology of Atherosclerosis: Different Players.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Laura Díez-RicoteNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
Paloma Ruiz-ValderreyNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
Víctor MicóNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
Ruth Blanco-RojoNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
João Tomé-CarneiroBioactive Food Ingredients Group, Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.ORCID 0000-0002-3597-9234
Alberto DávalosEpigenetics of Lipid Metabolism Group, Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
José M OrdovásNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.
Lidia DaimielNutritional Control of the Epigenome Group, Precision Nutrition and Obesity Program, IMDEA Food, UAM + CSIC, 28049 Madrid, Spain.ORCID 0000-0001-9898-6629
Madrid Institute for Advanced Studies · ES

Funding

Agencia Estatal de Investigación, Spain PID2019-109369RB-I0Comunidad de Madrid Programa de Garantía Juvenil 2018Fundación Cerveza y Salud Beca Manuel de Oya de InvestigaciónFundación Salud 2000 - Merck Serono Beca de Investigación 2013Instituto de Salud Carlos III PI14/01374Instituto de Salud Carlos III PI17/00508Ministerio de Ciencia e Innovación, Spain RTI2018-095569-B-I00
6 · The paper itself

Abstract

Diet is a well-known risk factor of cardiovascular diseases (CVDs). Some microRNAs (miRNAs) have been described to regulate molecular pathways related to CVDs. Diet can modulate miRNAs and their target genes. Choline, betaine, and l-carnitine, nutrients found in animal products, are metabolized into trimethylamine

Indexed as

AnimalsCardiovascular DiseasesCells, CulturedGene Expression RegulationHep G2 CellsHumansMaleMethylaminesMiceMice, Inbred C57BLMicroRNAsPeriod Circadian ProteinsTHP-1 CellsMethylaminesMicroRNAsPER2 protein, humanPeriod Circadian Proteinstrimethyloxamineatherosclerosiscardiovascular diseaseepigeneticsmiRNAsnutritiontarget genesTMAO

Identifiers

PMID34681805
PMCPMC8539082
OpenAlexW3207800476

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.