Evidence mapPaperPMID 34683161Full record

ArticleJournal of personalized medicine2021

Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study.

Ya-Ke Wu, Kimberly A Brownley, Anna M Bardone-Cone, Cynthia M Bulik, Jessica H Baker

Open access · goldAbstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Ya-Ke WuSchool of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8990-3449
Kimberly A BrownleyDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anna M Bardone-ConeDepartment of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-7772-3264
Jessica H BakerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
University of North Carolina at Chapel Hill · US

Funding

INTERVENTIONS FOR PREVENTING &MANAGING CHRONIC ILLNESST32NR007091 · UNIV OF NORTH CAROLINA CHAPEL HILL · 1996 to 2025
$3.1M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Laura Marianne Huckins · 2021 to 2022
$1.4M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · UNIV OF NORTH CAROLINA CHAPEL HILL · 2025 to 2025
$719k
Brain and Behavior Research Foundation Distinguished Investigator GrantLundbeckfonden R276-2018-4581National Institute of Mental Health K01 MH106675National Institute of Mental Health R01 MH095860National Institute of Mental Health R01 MH118278National Institute of Mental Health R01 MH119084National Institute of Mental Health R01 MH120170National Institute of Mental Health R01 MH124871National Institute of Nursing Research T32 NR007091Swedish Research Council Vetenskapsrådet, award: 538-2013-8864
6 · The paper itself

Abstract

Binge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this exploratory study of 73 females with AN were: (1) to examine changes in cortisol, the adrenocorticotropic hormone, norepinephrine, ghrelin (total and active), and leptin levels across the admission, discharge, and 3 months post-discharge from the inpatient AN weight restoration; and (2) to determine whether the target hormones were associated with objective or subjective binge eating (OBE or SBE). The participants completed the self-reported Eating Disorder Examination Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory-II, and provided fasting whole blood samples for hormone assays. The results showed significant changes in body mass index (BMI), cortisol, total ghrelin, and leptin levels over the three time points. The cortisol levels at admission and discharge were significantly associated with the number of SBE episodes at 3 months post-discharge. Findings suggest the need to replicate and confirm the role of cortisol in predicting the emergence of SBE and uncover the mechanisms underlying SBE and cortisol to prevent SBE and its negative consequences.

Indexed as

appetite hormonesloss of control eatingrenourishmentstress hormones

Identifiers

PMID34683161
PMCPMC8538976
OpenAlexW3206065306

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.