Evidence map›Paper›PMID 34684490›Full record

ReviewNutrients2021

Intermittent Fasting and Sleep: A Review of Human Trials.

Mara McStay, Kelsey Gabel, Sofia Cienfuegos, Mark Ezpeleta, Shuhao Lin, Krista A Varady

Open access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Sleep and chrononutrition: a narrative review.Sleep and biological rhythms · 2025
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Dieting Behavior Characterized by Caloric Restriction and Relation to Sleep: A Brief Contemporary Review.International journal of environmental research and public health · 2022
    Review
  18. Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Mara McStayDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.
Kelsey GabelDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.ORCID 0000-0003-4613-8892
Sofia CienfuegosDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.
Mark EzpeletaDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.
Shuhao LinDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.ORCID 0000-0002-7982-746X
Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, IL 60045, USA.
University of Illinois Chicago · US

Funding

Alternate day fasting combined with exercise for the treatment of NAFLDR01DK119783 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VARADY, KRISTA AMY · 2019 to 2022
$1.4M
NIDDK NIH HHS R01DK119783
6 · The paper itself

Abstract

This review examines the effects of two popular intermittent fasting regimens on sleep in adults with overweight and obesity. Specifically, the effects of time restricted eating (TRE; eating all food within a 4-10 h window) and alternate day fasting (ADF; 600 kcal fast day alternated with ad libitum feast day) on sleep quality, sleep duration, sleep latency, sleep efficiency, insomnia severity, and risk of obstructive sleep apnea, will be summarized. The role of weight loss will also be discussed. Results from our review reveal that the majority of these trials produced weight loss in the range of 1-6% from baseline. Sleep quality and sleep duration remained unaltered with TRE and ADF, as assessed by the Pittsburgh Sleep Quality Index (PSQI). The effects of intermittent fasting on sleep latency and sleep efficiency are mixed, with one study showing worsening of these parameters, and others showing no effect. Insomnia severity and the risk of obstructive sleep apnea remained unchanged in the trials assessing these metrics. Taken together, these preliminary findings suggest that TRE and ADF produce mild to moderate weight loss (1-6%) but their effects on sleep remain unclear. Solid conclusions are difficult to establish since participants in the studies had healthy sleep durations and no clinical insomnia at baseline, leaving little room for improvement in these metrics. Moreover, none of the trials were adequately powered to detect statistically significant changes in any measure of sleep. Future well-powered trials, conducted in individuals with diagnosed sleep disturbances, will be necessary to elucidate the effect of these popular diets on sleep.

Indexed as

AdultCaloric RestrictionClinical Trials as TopicFastingFemaleHumansMaleMiddle AgedObesityOverweightSleepSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersWeight Lossalternate day fastinginsomniaintermittent fastingobesitysleep apneasleep durationsleep qualitytime restricted eating

Identifiers

PMID34684490
PMCPMC8539054
OpenAlexW3204496434

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.