Evidence map›Paper›PMID 34684879›Full record

ArticleMolecules (Basel, Switzerland)2021

Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release.

Rami Lee, Sun-Hye Choi, Han-Sung Cho, Hongik Hwang, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Rami LeeGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
Sun-Hye ChoiGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
Han-Sung ChoGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.
Hongik HwangCenter for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, Korea.ORCID 0000-0002-6363-9579
Hyewhon RhimCenter for Neuroscience, Korea Institute of Science and Technology, Seoul 02792, Korea.
Hyoung-Chun KimNeuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon 24341, Korea.ORCID 0000-0003-0420-795X
Sung-Hee HwangDepartment of Pharmaceutical Engineering, College of Health Sciences, Sangji University, Wonju 26339, Korea.
Seung-Yeol NahGinsentology Research Laboratory, Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea.ORCID 0000-0001-9697-4763
Konkuk University · KRKorea Institute of Science and Technology · KRKangwon National University · KRSangji University · KR

Funding

National Research Foundation of Korea 2020R1F1A1067427National Research Foundation of Korea 2020RIFIA1058460
6 · The paper itself

Abstract

Ginseng-derived gintonin reportedly contains functional lysophosphatidic acids (LPAs) as LPA receptor ligands. The effect of the gintonin-enriched fraction (GEF) on in vitro and in vivo glucagon-like protein-1 (GLP-1) secretion, which is known to stimulate insulin secretion, via LPA receptor(s) remains unclear. Accordingly, we examined the effects of GEF on GLP-1 secretion using human enteroendocrine NCI-H716 cells. The expression of several of LPA receptor subtypes in NCI-H716 cells using qPCR and Western blotting was examined. LPA receptor subtype expression was in the following order: LPA6 > LPA2 > LPA4 > LPA5 > LPA1 (qPCR), and LPA6 > LPA4 > LPA2 > LPA1 > LPA3 > LPA5 (Western blotting). GEF-stimulated GLP-1 secretion occurred in a dose- and time-dependent manner, which was suppressed by cAMP-Rp, a cAMP antagonist, but not by U73122, a phospholipase C inhibitor. Furthermore, silencing the human LPA6 receptor attenuated GEF-mediated GLP-1 secretion. In mice, low-dose GEF (50 mg/kg, peroral) increased serum GLP-1 levels; this effect was not blocked by Ki16425 co-treatment. Our findings indicate that GEF-induced GLP-1 secretion could be achieved via LPA6 receptor activation through the cAMP pathway. Hence, GEF-induced GLP secretion via LPA6 receptor regulation might be responsible for its beneficial effects on human endocrine physiology.

Indexed as

AnimalsColorectal NeoplasmsGlucagonGlucagon-Like Peptide 1HumansInsulin SecretionLysophospholipidsMaleMiceMice, Inbred ICRPanaxPlant ExtractsReceptors, Lysophosphatidic AcidSignal TransductionTumor Cells, CulturedgintoninGlucagonGlucagon-Like Peptide 1LysophospholipidsPlant ExtractsReceptors, Lysophosphatidic Acidginsenggintoningintonin-enriched fractionGLP-1 secretionNCI-H716 cell

Identifiers

PMID34684879
PMCPMC8539011
OpenAlexW3207354627

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.